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Fusion gene ID: 9728

FusionGeneSummary for DENND3_DENND3

Fusion gene summary

Fusion gene information	Fusion gene name: DENND3_DENND3
	Fusion gene ID: 9728
		Hgene	Tgene
	Gene symbol	DENND3	DENND3
	Gene ID	22898	22898
	Gene name	DENN domain containing 3	DENN domain containing 3
	Synonyms	-	-
	Cytomap	8q24.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	DENN domain-containing protein 3DENN/MADD domain containing 3	DENN domain-containing protein 3DENN/MADD domain containing 3
	Modification date	20180519	20180519
	UniProtAcc	A2RUS2	A2RUS2
	Ensembl transtripts involved in fusion gene	ENST00000518347, ENST00000424248, ENST00000262585, ENST00000519811, ENST00000518806, ENST00000523308,	ENST00000518347, ENST00000424248, ENST00000262585, ENST00000519811, ENST00000518806, ENST00000523308,
Fusion gene scores	* DoF score	3 X 3 X 2=18	5 X 5 X 5=125
	# samples	4	6
	** MAII score	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DENND3 [Title/Abstract] AND DENND3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA449866	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000518347	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518347	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518347	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518347	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518347	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518347	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000424248	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000262585	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000519811	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000518806	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000518347	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000424248	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000262585	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000519811	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000518806	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+
intron-intron	ENST00000523308	ENST00000523308	DENND3	chr8	142203974	+	DENND3	chr8	142202644	+

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FusionProtFeatures for DENND3_DENND3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DENND3 A2RUS2	DENND3 A2RUS2

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Fusion gene ID: 9728

FusionGeneSummary for DENND3_DENND3

FusionProtFeatures for DENND3_DENND3