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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 9720

FusionGeneSummary for DENND1B_RCOR3

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B_RCOR3
Fusion gene ID: 9720
HgeneTgene
Gene symbol

DENND1B

RCOR3

Gene ID

163486

55758

Gene nameDENN domain containing 1BREST corepressor 3
SynonymsC1ORF18|C1orf218|FAM31B-
Cytomap

1q31.3

1q32.2-q32.3

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member BREST corepressor 3
Modification date2018052320180523
UniProtAcc

Q6P3S1

Q9P2K3

Ensembl transtripts involved in fusion geneENST00000400967, ENST00000235453, 
ENST00000367396, ENST00000477581, 
ENST00000367006, ENST00000452621, 
ENST00000419091, ENST00000367005, 
ENST00000526255, 
Fusion gene scores* DoF score7 X 3 X 5=1052 X 3 X 2=12
# samples 72
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DENND1B [Title/Abstract] AND RCOR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-50-5932-01ADENND1Bchr1

197684161

-RCOR3chr1

211432921

+
TCGALDLUADTCGA-50-5932-01ADENND1Bchr1

197684161

-RCOR3chr1

211433450

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400967ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000400967ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000400967ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000400967ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000400967ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000235453ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000235453ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000235453ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000235453ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000235453ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
In-frameENST00000367396ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000367396ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000367396ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000367396ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
5CDS-intronENST00000367396ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
intron-3CDSENST00000477581ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
intron-3CDSENST00000477581ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
intron-3CDSENST00000477581ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
intron-intronENST00000477581ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
intron-intronENST00000477581ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211432921

+
Frame-shiftENST00000400967ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000400967ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000400967ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-5UTRENST00000400967ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-intronENST00000400967ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000235453ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000235453ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000235453ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-5UTRENST00000235453ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-intronENST00000235453ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000367396ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000367396ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
Frame-shiftENST00000367396ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-5UTRENST00000367396ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
5CDS-intronENST00000367396ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
intron-3CDSENST00000477581ENST00000367006DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
intron-3CDSENST00000477581ENST00000452621DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
intron-3CDSENST00000477581ENST00000419091DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
intron-5UTRENST00000477581ENST00000367005DENND1Bchr1

197684161

-RCOR3chr1

211433450

+
intron-intronENST00000477581ENST00000526255DENND1Bchr1

197684161

-RCOR3chr1

211433450

+

Top

FusionProtFeatures for DENND1B_RCOR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1B

Q6P3S1

RCOR3

Q9P2K3

May act as a component of a corepressor complex thatrepresses transcription. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367005+011237_273-47496Coiled coilOntology_term=ECO:0000255
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367006+011237_273-94437Coiled coilOntology_term=ECO:0000255
TgeneRCOR3chr1:197684161chr1:211432921ENST00000419091+012237_273-43554Coiled coilOntology_term=ECO:0000255
TgeneRCOR3chr1:197684161chr1:211432921ENST00000452621+011237_273-58450Coiled coilOntology_term=ECO:0000255
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367005+011385_481-47496Compositional biasNote=Pro-rich
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367006+011385_481-94437Compositional biasNote=Pro-rich
TgeneRCOR3chr1:197684161chr1:211432921ENST00000419091+012385_481-43554Compositional biasNote=Pro-rich
TgeneRCOR3chr1:197684161chr1:211432921ENST00000452621+011385_481-58450Compositional biasNote=Pro-rich
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367005+0111_83-47496DomainELM2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367005+011285_336-47496DomainSANT 2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367005+01184_135-47496DomainSANT 1
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367006+0111_83-94437DomainELM2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367006+011285_336-94437DomainSANT 2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000367006+01184_135-94437DomainSANT 1
TgeneRCOR3chr1:197684161chr1:211432921ENST00000419091+0121_83-43554DomainELM2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000419091+012285_336-43554DomainSANT 2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000419091+01284_135-43554DomainSANT 1
TgeneRCOR3chr1:197684161chr1:211432921ENST00000452621+0111_83-58450DomainELM2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000452621+011285_336-58450DomainSANT 2
TgeneRCOR3chr1:197684161chr1:211432921ENST00000452621+01184_135-58450DomainSANT 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000235453-41614_14332397DomainuDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000235453-416180_31632397DomaincDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000235453-416318_39532397DomaindDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000367396-31614_14342427DomainuDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000367396-316180_31642427DomaincDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000367396-316318_39542427DomaindDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000400967-21414_14332397DomainuDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000400967-214180_31632397DomaincDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000400967-214318_39532397DomaindDENN
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000235453-416398_40232397MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000235453-416566_57532397MotifClathrin box
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000367396-316398_40242427MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000367396-316566_57542427MotifClathrin box
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000400967-214398_40232397MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:211432921ENST00000400967-214566_57532397MotifClathrin box


Top

FusionGeneSequence for DENND1B_RCOR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DENND1B_ENST00000400967_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_563aa
MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQRARCGRGAPGTARGGRRRREEGREAGPGRVVVRRLRYCRSGAVMAAPYXQPPPPPPPP
PSPPPPPFPPARALSHLRLHPDACLFPSPFPLPCSTMPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDE
HDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFP
DEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPK
KEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSAL
KQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGTDPTGSSDTGSITSCPIIHSNTNSPYCHSEPASTTSSSNTACCPGSSPAASSTPA

>In-frame_DENND1B_ENST00000367396_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_573aa
MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQRARCGRGAPGTARGGRRRREEGREAGPGRVVVRRLRYCRSGAVMAAPY
XQPPPPPPPPPSPPPPPFPPARALSHLRLHPDACLFPSPFPLPCSTMPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSE
PESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSL
ADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPM
DGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQV
QNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGTDPTGSSDTGSITSCPIIHSNTNSPYCHSEPASTTSSSNTACCPG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DENND1B_ENST00000400967_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_1689nt
ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA
GACCAGAGAGCGCGGTGCGGCCGAGGGGCGCCCGGGACTGCGCGGGGCGGGCGGCGGCGGAGGGAGGAGGGGAGAGAGGCGGGGCCGGGG
CGGGTTGTTGTGAGGCGACTGCGCTACTGCCGGAGCGGGGCGGTTATGGCGGCTCCATATTAACAGCCTCCTCCTCCTCCGCCGCCGCCG
CCGTCTCCTCCTCCTCCTCCTTTCCCTCCCGCCCGCGCTCTAAGCCATCTCCGCCTTCACCCTGACGCCTGCCTCTTCCCCTCACCTTTC
CCCCTCCCCTGTTCTACCATGCCCGGCATGATGGAGAAAGGGCCCGAGTTACTGGGGAAGAACCGATCGGCCAACGGCAGCGCCAAGAGC
CCGGCAGGCGGCGGCGGCAGCGGCGCCTCGTCCACCAACGGCGGGCTGCACTACTCAGAGCCCGAGAGCGGCTGCAGCAGCGACGACGAG
CACGATGTTGGGATGAGAGTCGGAGCCGAATACCAAGCTCGGATCCCTGAATTTGATCCAGGTGCTACAAAGTACACAGATAAAGACAAT
GGAGGGATGCTTGTATGGTCTCCATATCACAGTATCCCAGATGCCAAATTGGATGAATACATTGCAATTGCAAAGGAAAAGCATGGCTAC
AATGTGGAACAGGCACTTGGCATGTTGTTCTGGCATAAACATAACATTGAGAAGTCCCTTGCTGATCTCCCTAATTTCACTCCCTTTCCG
GATGAGTGGACAGTGGAAGATAAAGTCCTATTTGAACAAGCCTTTAGTTTTCATGGAAAGAGCTTTCACAGGATTCAGCAAATGCTTCCA
GATAAGACAATTGCAAGCCTTGTAAAATATTACTATTCTTGGAAAAAAACTCGCTCTAGGACAAGTTTGATGGATCGCCAGGCTCGTAAA
CTAGCTAATAGACATAATCAGGGTGACAGTGATGATGATGTAGAAGAAACACATCCAATGGATGGGAATGATAGTGATTATGATCCCAAA
AAAGAAGCCAAAAAAGAGGGTAATACTGAACAACCTGTCCAAACTAGCAAGATTGGACTTGGAAGAAGAGAGTATCAGAGTTTACAACAT
CGCCATCATTCTCAGCGTTCTAAGTGCCGTCCACCTAAGGGCATGTATTTAACCCAGGAAGATGTGGTAGCAGTTTCCTGTAGTCCCAAT
GCAGCCAACACCATCCTGAGGCAACTGGACATGGAGTTGATCTCTCTAAAACGTCAGGTTCAGAATGCTAAGCAAGTAAACAGTGCACTT
AAACAGAAAATGGAAGGTGGAATTGAAGAATTCAAACCTCCTGAGTCAAATCAGAAAATTAATGCCCGTTGGACCACAGAGGAGCAGCTT
CTAGCAGTGCAAGGCACAGACCCCACAGGCTCCTCGGACACTGGGTCCATCACCTCCTGCCCCATCATCCACTCCAACACCAACAGCCCC
TATTGCCACTCTGAACCAGCCTCCACCACTTCTTCGTCCAACACTGCCTGCTGCCCCGGCTCTTCACCGGCAGCCTCCTCCACTCCAGCA

>In-frame_DENND1B_ENST00000367396_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_1719nt
ATGGACTGCAGGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTG
GTATTGTGGAAATTCCCAGAGGACTTTGGAGACCAGAGAGCGCGGTGCGGCCGAGGGGCGCCCGGGACTGCGCGGGGCGGGCGGCGGCGG
AGGGAGGAGGGGAGAGAGGCGGGGCCGGGGCGGGTTGTTGTGAGGCGACTGCGCTACTGCCGGAGCGGGGCGGTTATGGCGGCTCCATAT
TAACAGCCTCCTCCTCCTCCGCCGCCGCCGCCGTCTCCTCCTCCTCCTCCTTTCCCTCCCGCCCGCGCTCTAAGCCATCTCCGCCTTCAC
CCTGACGCCTGCCTCTTCCCCTCACCTTTCCCCCTCCCCTGTTCTACCATGCCCGGCATGATGGAGAAAGGGCCCGAGTTACTGGGGAAG
AACCGATCGGCCAACGGCAGCGCCAAGAGCCCGGCAGGCGGCGGCGGCAGCGGCGCCTCGTCCACCAACGGCGGGCTGCACTACTCAGAG
CCCGAGAGCGGCTGCAGCAGCGACGACGAGCACGATGTTGGGATGAGAGTCGGAGCCGAATACCAAGCTCGGATCCCTGAATTTGATCCA
GGTGCTACAAAGTACACAGATAAAGACAATGGAGGGATGCTTGTATGGTCTCCATATCACAGTATCCCAGATGCCAAATTGGATGAATAC
ATTGCAATTGCAAAGGAAAAGCATGGCTACAATGTGGAACAGGCACTTGGCATGTTGTTCTGGCATAAACATAACATTGAGAAGTCCCTT
GCTGATCTCCCTAATTTCACTCCCTTTCCGGATGAGTGGACAGTGGAAGATAAAGTCCTATTTGAACAAGCCTTTAGTTTTCATGGAAAG
AGCTTTCACAGGATTCAGCAAATGCTTCCAGATAAGACAATTGCAAGCCTTGTAAAATATTACTATTCTTGGAAAAAAACTCGCTCTAGG
ACAAGTTTGATGGATCGCCAGGCTCGTAAACTAGCTAATAGACATAATCAGGGTGACAGTGATGATGATGTAGAAGAAACACATCCAATG
GATGGGAATGATAGTGATTATGATCCCAAAAAAGAAGCCAAAAAAGAGGGTAATACTGAACAACCTGTCCAAACTAGCAAGATTGGACTT
GGAAGAAGAGAGTATCAGAGTTTACAACATCGCCATCATTCTCAGCGTTCTAAGTGCCGTCCACCTAAGGGCATGTATTTAACCCAGGAA
GATGTGGTAGCAGTTTCCTGTAGTCCCAATGCAGCCAACACCATCCTGAGGCAACTGGACATGGAGTTGATCTCTCTAAAACGTCAGGTT
CAGAATGCTAAGCAAGTAAACAGTGCACTTAAACAGAAAATGGAAGGTGGAATTGAAGAATTCAAACCTCCTGAGTCAAATCAGAAAATT
AATGCCCGTTGGACCACAGAGGAGCAGCTTCTAGCAGTGCAAGGCACAGACCCCACAGGCTCCTCGGACACTGGGTCCATCACCTCCTGC
CCCATCATCCACTCCAACACCAACAGCCCCTATTGCCACTCTGAACCAGCCTCCACCACTTCTTCGTCCAACACTGCCTGCTGCCCCGGC
TCTTCACCGGCAGCCTCCTCCACTCCAGCAGCAGGCTCGGTTCATCCAGCCCCGGCCAACTTTAAATCAGCCTCCACCACCTCTTATTCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DENND1B_ENST00000400967_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_2320nt
ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA
GACCAGAAGGGCCCGAGTTACTGGGGAAGAACCGATCGGCCAACGGCAGCGCCAAGAGCCCGGCAGGCGGCGGCGGCAGCGGCGCCTCGT
CCACCAACGGCGGGCTGCACTACTCAGAGCCCGAGAGCGGCTGCAGCAGCGACGACGAGCACGATGTTGGGATGAGAGTCGGAGCCGAAT
ACCAAGCTCGGATCCCTGAATTTGATCCAGGTGCTACAAAGTACACAGATAAAGACAATGGAGGGATGCTTGTATGGTCTCCATATCACA
GTATCCCAGATGCCAAATTGGATGAATACATTGCAATTGCAAAGGAAAAGCATGGCTACAATGTGGAACAGGCACTTGGCATGTTGTTCT
GGCATAAACATAACATTGAGAAGTCCCTTGCTGATCTCCCTAATTTCACTCCCTTTCCGGATGAGTGGACAGTGGAAGATAAAGTCCTAT
TTGAACAAGCCTTTAGTTTTCATGGAAAGAGCTTTCACAGGATTCAGCAAATGCTTCCAGATAAGACAATTGCAAGCCTTGTAAAATATT
ACTATTCTTGGAAAAAAACTCGCTCTAGGACAAGTTTGATGGATCGCCAGGCTCGTAAACTAGCTAATAGACATAATCAGGGTGACAGTG
ATGATGATGTAGAAGAAACACATCCAATGGATGGGAATGATAGTGATTATGATCCCAAAAAAGAAGCCAAAAAAGAGGGTAATACTGAAC
AACCTGTCCAAACTAGCAAGATTGGACTTGGAAGAAGAGAGTATCAGAGTTTACAACATCGCCATCATTCTCAGCGTTCTAAGTGCCGTC
CACCTAAGGGCATGTATTTAACCCAGGAAGATGTGGTAGCAGTTTCCTGTAGTCCCAATGCAGCCAACACCATCCTGAGGCAACTGGACA
TGGAGTTGATCTCTCTAAAACGTCAGGTTCAGAATGCTAAGCAAGTAAACAGTGCACTTAAACAGAAAATGGAAGGTGGAATTGAAGAAT
TCAAACCTCCTGAGTCAAATCAGAAAATTAATGCCCGTTGGACCACAGAGGAGCAGCTTCTAGCAGTGCAAGGCACAGACCCCACAGGCT
CCTCGGACACTGGGTCCATCACCTCCTGCCCCATCATCCACTCCAACACCAACAGCCCCTATTGCCACTCTGAACCAGCCTCCACCACTT
CTTCGTCCAACACTGCCTGCTGCCCCGGCTCTTCACCGGCAGCCTCCTCCACTCCAGCAGCAGGCTCGGTTCATCCAGCCCCGGCCAACT
TTAAATCAGCCTCCACCACCTCTTATTCGCCCTGCTAATTCCATGCCACCCCGTCTAAACCCAAGACCGGTGTTGTCCACGGTTGGTGGT
CAACAGCCACCATCACTTATTGGAATTCAGACAGATTCACAGTCCTCACTGCACTAAAAATTAAATTGGACACAGCTGCAGTAACTTTTC
ACCCCATCATTATACCAGTGCTCATCTGACTGATGAAAAAGAGGAAAGAATAATCATTTCTAGATACTGAGGCTGCGAACTAGTTCTGTG
GCAGTGGACTAGCATAAGTGGATGTCTAAGAAATTTTTCAGTTCACTAGACTAAAATGTTTTACAACAAAAAGCCTCCAGTTAGCCTCCT
TTCTAGAGTATATGTTCAGCAATGTTGATCTCATAAAAGGAAAAACAAAAGATTTAAGTATTCTATATACCAAGTTTTTGTTTTGTTTTT
ACTGTATTTATTTTATTGAGGTTCTTTATATTCCTGCCTCTTCATAGTCAAGGCTCTTAGTACAGGAATATTGACTTAGGAATTGTGAAA
ACTCCTTAAGTTTCTTAAGTTAAGGATGTTTGGCTTTTTTCTTTAATTTTTTAAAAACCATTTTCCTATGTTAGGAGTGCAAGAATAGCC
AGCATTTCCGATTTTGACATATGTTCATTTTATGCATATTTAAGAAATTATAGCTGCATATCCCTTCTTTCAAAAAATGTTGCTTTTTTT
TTTAAAGGAATTTTAATATATTCCTTTAAAAGAAAGCAATTTAATCAATTGCAAAGCAATTATATAAAACCACAAAGAATGTACTGAACC
TACTAACCCTTTAACATACAGTTTAGGGTCCTAGCGCAGAGTCCTTGTTTAAAGGTCATTGACTCATCATCTGTCAGTAATGAGAGGATT

>In-frame_DENND1B_ENST00000367396_chr1_197684161_-_RCOR3_ENST00000367006_chr1_211432921_+_2520nt
GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG
CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA
GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTGGTATTGTGGA
AATTCCCAGAGGACTTTGGAGACCAGAAGGGCCCGAGTTACTGGGGAAGAACCGATCGGCCAACGGCAGCGCCAAGAGCCCGGCAGGCGG
CGGCGGCAGCGGCGCCTCGTCCACCAACGGCGGGCTGCACTACTCAGAGCCCGAGAGCGGCTGCAGCAGCGACGACGAGCACGATGTTGG
GATGAGAGTCGGAGCCGAATACCAAGCTCGGATCCCTGAATTTGATCCAGGTGCTACAAAGTACACAGATAAAGACAATGGAGGGATGCT
TGTATGGTCTCCATATCACAGTATCCCAGATGCCAAATTGGATGAATACATTGCAATTGCAAAGGAAAAGCATGGCTACAATGTGGAACA
GGCACTTGGCATGTTGTTCTGGCATAAACATAACATTGAGAAGTCCCTTGCTGATCTCCCTAATTTCACTCCCTTTCCGGATGAGTGGAC
AGTGGAAGATAAAGTCCTATTTGAACAAGCCTTTAGTTTTCATGGAAAGAGCTTTCACAGGATTCAGCAAATGCTTCCAGATAAGACAAT
TGCAAGCCTTGTAAAATATTACTATTCTTGGAAAAAAACTCGCTCTAGGACAAGTTTGATGGATCGCCAGGCTCGTAAACTAGCTAATAG
ACATAATCAGGGTGACAGTGATGATGATGTAGAAGAAACACATCCAATGGATGGGAATGATAGTGATTATGATCCCAAAAAAGAAGCCAA
AAAAGAGGGTAATACTGAACAACCTGTCCAAACTAGCAAGATTGGACTTGGAAGAAGAGAGTATCAGAGTTTACAACATCGCCATCATTC
TCAGCGTTCTAAGTGCCGTCCACCTAAGGGCATGTATTTAACCCAGGAAGATGTGGTAGCAGTTTCCTGTAGTCCCAATGCAGCCAACAC
CATCCTGAGGCAACTGGACATGGAGTTGATCTCTCTAAAACGTCAGGTTCAGAATGCTAAGCAAGTAAACAGTGCACTTAAACAGAAAAT
GGAAGGTGGAATTGAAGAATTCAAACCTCCTGAGTCAAATCAGAAAATTAATGCCCGTTGGACCACAGAGGAGCAGCTTCTAGCAGTGCA
AGGCACAGACCCCACAGGCTCCTCGGACACTGGGTCCATCACCTCCTGCCCCATCATCCACTCCAACACCAACAGCCCCTATTGCCACTC
TGAACCAGCCTCCACCACTTCTTCGTCCAACACTGCCTGCTGCCCCGGCTCTTCACCGGCAGCCTCCTCCACTCCAGCAGCAGGCTCGGT
TCATCCAGCCCCGGCCAACTTTAAATCAGCCTCCACCACCTCTTATTCGCCCTGCTAATTCCATGCCACCCCGTCTAAACCCAAGACCGG
TGTTGTCCACGGTTGGTGGTCAACAGCCACCATCACTTATTGGAATTCAGACAGATTCACAGTCCTCACTGCACTAAAAATTAAATTGGA
CACAGCTGCAGTAACTTTTCACCCCATCATTATACCAGTGCTCATCTGACTGATGAAAAAGAGGAAAGAATAATCATTTCTAGATACTGA
GGCTGCGAACTAGTTCTGTGGCAGTGGACTAGCATAAGTGGATGTCTAAGAAATTTTTCAGTTCACTAGACTAAAATGTTTTACAACAAA
AAGCCTCCAGTTAGCCTCCTTTCTAGAGTATATGTTCAGCAATGTTGATCTCATAAAAGGAAAAACAAAAGATTTAAGTATTCTATATAC
CAAGTTTTTGTTTTGTTTTTACTGTATTTATTTTATTGAGGTTCTTTATATTCCTGCCTCTTCATAGTCAAGGCTCTTAGTACAGGAATA
TTGACTTAGGAATTGTGAAAACTCCTTAAGTTTCTTAAGTTAAGGATGTTTGGCTTTTTTCTTTAATTTTTTAAAAACCATTTTCCTATG
TTAGGAGTGCAAGAATAGCCAGCATTTCCGATTTTGACATATGTTCATTTTATGCATATTTAAGAAATTATAGCTGCATATCCCTTCTTT
CAAAAAATGTTGCTTTTTTTTTTAAAGGAATTTTAATATATTCCTTTAAAAGAAAGCAATTTAATCAATTGCAAAGCAATTATATAAAAC
CACAAAGAATGTACTGAACCTACTAACCCTTTAACATACAGTTTAGGGTCCTAGCGCAGAGTCCTTGTTTAAAGGTCATTGACTCATCAT
CTGTCAGTAATGAGAGGATTGGAAGAATAATTTTGCATACAAATGAGGACTTAATTTGTTGAAATATAATCTCTTTAAGTTCCTTGAAAA


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FusionGenePPI for DENND1B_RCOR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DENND1BSERPINA12, XPO1RCOR3CEP70, KRT15, NECAB2, GSE1, NINL, ELAVL1, APP, MYC, HDAC1, HDAC2, KDM1A, MTA3, HDAC3, YWHAQ, CDR2, GOLGA2, KRT31, MAGEA6, TRIM27, TRAF2, MID2, IKZF3, TFIP11, LUZP4, CEP55, TRIM54, PRDM14, CCDC102B, TSGA10, LZTS2, KRT40, MIPOL1, LCA5, TXLNA, TRIM42, SUMO2, ECE2, ATP5F1, SNAI1, MAGEA1, HMG20B, FGF1, DOK4, CTBP1, ARRDC1, CEP19, HMG20A, ZSCAN5A, DCAF12L2, LLGL2, MXD3, MVP, PCK2, ZNF202, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DENND1B_RCOR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DENND1B_RCOR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND1BC0010346Crohn Disease1CTD_human
HgeneDENND1BC0023892Biliary cirrhosis1CTD_human