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Fusion gene ID: 9711 |
FusionGeneSummary for DENND1A_PBX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND1A_PBX3 | Fusion gene ID: 9711 | Hgene | Tgene | Gene symbol | DENND1A | PBX3 | Gene ID | 57706 | 5090 |
| Gene name | DENN domain containing 1A | PBX homeobox 3 | |
| Synonyms | FAM31A|KIAA1608 | - | |
| Cytomap | 9q33.3 | 9q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1 | pre-B-cell leukemia transcription factor 3homeobox protein PBX3pre-B-cell leukemia homeobox 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TEH3 | P40426 | |
| Ensembl transtripts involved in fusion gene | ENST00000473039, ENST00000373624, ENST00000542603, ENST00000394219, ENST00000373620, ENST00000394215, ENST00000373618, | ENST00000342287, ENST00000373487, ENST00000373489, ENST00000373483, ENST00000447726, ENST00000538998, | |
| Fusion gene scores | * DoF score | 13 X 8 X 10=1040 | 7 X 4 X 5=140 |
| # samples | 14 | 8 | |
| ** MAII score | log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DENND1A [Title/Abstract] AND PBX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DENND1A | GO:0032483 | regulation of Rab protein signal transduction | 20937701 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HI-7171-01A | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000473039 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5UTR-3CDS | ENST00000473039 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5UTR-3CDS | ENST00000473039 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5UTR-5UTR | ENST00000473039 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5UTR-5UTR | ENST00000473039 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5UTR-3UTR | ENST00000473039 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373624 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373624 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373624 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373624 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373624 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000373624 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000542603 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000542603 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000542603 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000542603 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000542603 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000542603 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000394219 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000394219 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000394219 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000394219 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000394219 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000394219 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373620 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373620 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| In-frame | ENST00000373620 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373620 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373620 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000373620 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000394215 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000394215 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000394215 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000394215 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000394215 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000394215 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000373618 | ENST00000342287 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000373618 | ENST00000373487 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| Frame-shift | ENST00000373618 | ENST00000373489 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373618 | ENST00000373483 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-5UTR | ENST00000373618 | ENST00000447726 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
| 5CDS-3UTR | ENST00000373618 | ENST00000538998 | DENND1A | chr9 | 126345448 | - | PBX3 | chr9 | 128691934 | + |
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FusionProtFeatures for DENND1A_PBX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND1A | PBX3 |