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Fusion gene ID: 9665 |
FusionGeneSummary for DDX60L_DSCAM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX60L_DSCAM | Fusion gene ID: 9665 | Hgene | Tgene | Gene symbol | DDX60L | DSCAM | Gene ID | 91351 | 1826 |
| Gene name | DExD/H-box 60 like | DS cell adhesion molecule | |
| Synonyms | - | CHD2|CHD2-42|CHD2-52 | |
| Cytomap | 4q32.3 | 21q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX60-likeDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-likeDEAD box protein 60-likeDEAD-box helicase 60 likeputative ATP-dependent RNA helicase DDX60 | Down syndrome cell adhesion molecule | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5H9U9 | O60469 | |
| Ensembl transtripts involved in fusion gene | ENST00000260184, ENST00000511577, ENST00000505890, ENST00000515088, | ENST00000400454, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 6 X 5=270 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/270*10)=-1.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX60L [Title/Abstract] AND DSCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DSCAM | GO:0042327 | positive regulation of phosphorylation | 19196994 |
| Tgene | DSCAM | GO:0048842 | positive regulation of axon extension involved in axon guidance | 18585357 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-36-1574-01A | DDX60L | chr4 | 169374275 | - | DSCAM | chr21 | 41559914 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000260184 | ENST00000400454 | DDX60L | chr4 | 169374275 | - | DSCAM | chr21 | 41559914 | - |
| Frame-shift | ENST00000511577 | ENST00000400454 | DDX60L | chr4 | 169374275 | - | DSCAM | chr21 | 41559914 | - |
| Frame-shift | ENST00000505890 | ENST00000400454 | DDX60L | chr4 | 169374275 | - | DSCAM | chr21 | 41559914 | - |
| intron-3CDS | ENST00000515088 | ENST00000400454 | DDX60L | chr4 | 169374275 | - | DSCAM | chr21 | 41559914 | - |
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FusionProtFeatures for DDX60L_DSCAM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX60L | DSCAM |