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Fusion gene ID: 9646 |
FusionGeneSummary for DDX58_PRSS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX58_PRSS3 | Fusion gene ID: 9646 | Hgene | Tgene | Gene symbol | DDX58 | PRSS3 | Gene ID | 23586 | 5646 |
| Gene name | DExD/H-box helicase 58 | serine protease 3 | |
| Synonyms | RIG-I|RIGI|RLR-1|SGMRT2 | MTG|PRSS4|T9|TRY3|TRY4 | |
| Cytomap | 9p21.1 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58DEAD box protein 58DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRNA helicase RIG-Iretinoic acid-inducible gene 1 proteinretinoic acid-inducible gene I protein | trypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IV | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O95786 | P35030 | |
| Ensembl transtripts involved in fusion gene | ENST00000379882, ENST00000379868, ENST00000379883, ENST00000545044, ENST00000542096, | ENST00000361005, ENST00000342836, ENST00000429677, ENST00000379405, ENST00000495682, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 2 X 6=84 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX58 [Title/Abstract] AND PRSS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDX58 | GO:0009597 | detection of virus | 17079289 |
| Hgene | DDX58 | GO:0010628 | positive regulation of gene expression | 24409285 |
| Hgene | DDX58 | GO:0030334 | regulation of cell migration | 19122199 |
| Hgene | DDX58 | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | 24409285 |
| Hgene | DDX58 | GO:0032727 | positive regulation of interferon-alpha production | 19576794 |
| Hgene | DDX58 | GO:0032728 | positive regulation of interferon-beta production | 17079289 |
| Hgene | DDX58 | GO:0032755 | positive regulation of interleukin-6 production | 24409285 |
| Hgene | DDX58 | GO:0032757 | positive regulation of interleukin-8 production | 24409285 |
| Hgene | DDX58 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17079289 |
| Hgene | DDX58 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 17079289 |
| Hgene | DDX58 | GO:0051607 | defense response to virus | 21478870 |
| Tgene | PRSS3 | GO:0006508 | proteolysis | 6698368 |
| Tgene | PRSS3 | GO:0031638 | zymogen activation | 6698368 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4444-01A | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000379882 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-intron | ENST00000379882 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000379868 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5CDS-intron | ENST00000379883 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000545044 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000542096 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
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FusionProtFeatures for DDX58_PRSS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX58 | PRSS3 |