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Fusion gene ID: 9618 |
FusionGeneSummary for DDX42_HSF5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX42_HSF5 | Fusion gene ID: 9618 | Hgene | Tgene | Gene symbol | DDX42 | HSF5 | Gene ID | 11325 | 124535 |
| Gene name | DEAD-box helicase 42 | heat shock transcription factor 5 | |
| Synonyms | DDX42P|RHELP|RNAHP|SF3B8|SF3b125 | HSF 5|HSTF 5 | |
| Cytomap | 17q23.3 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent RNA helicase DDX42DEAD (Asp-Glu-Ala-Asp) box helicase 42DEAD (Asp-Glu-Ala-Asp) box polypeptide 42SF3b DEAD box proteinsplicing factor 3B-associated 125 kDa proteinsplicing factor 3b, subunit 8 | heat shock factor protein 5heat shock transcription factor family member 5 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86XP3 | Q4G112 | |
| Ensembl transtripts involved in fusion gene | ENST00000578681, ENST00000583590, ENST00000359353, ENST00000389924, ENST00000457800, ENST00000582985, | ENST00000323777, | |
| Fusion gene scores | * DoF score | 9 X 7 X 3=189 | 3 X 1 X 2=6 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/189*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: DDX42 [Title/Abstract] AND HSF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDX42 | GO:0008104 | protein localization | 19377511 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0X1-01A | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000578681 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| 5UTR-3CDS | ENST00000583590 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| 5UTR-3CDS | ENST00000359353 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| 5UTR-3CDS | ENST00000389924 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| intron-3CDS | ENST00000457800 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
| intron-3CDS | ENST00000582985 | ENST00000323777 | DDX42 | chr17 | 61851736 | + | HSF5 | chr17 | 56499791 | - |
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FusionProtFeatures for DDX42_HSF5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX42 | HSF5 |