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Fusion gene ID: 9595 |
FusionGeneSummary for DDX27_ATP9A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX27_ATP9A | Fusion gene ID: 9595 | Hgene | Tgene | Gene symbol | DDX27 | ATP9A | Gene ID | 55661 | 10079 |
| Gene name | DEAD-box helicase 27 | ATPase phospholipid transporting 9A (putative) | |
| Synonyms | DRS1|Drs1p|HSPC259|PP3241|RHLP|dJ686N3.1 | ATPIIA | |
| Cytomap | 20q13.13 | 20q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27DEAD box protein 27DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27Deficiency of ribosomal subunits protein 1 homologRNA helicase-like protein | probable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIA | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96GQ7 | O75110 | |
| Ensembl transtripts involved in fusion gene | ENST00000484427, ENST00000371764, | ENST00000311637, ENST00000338821, ENST00000402822, ENST00000477492, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 7 X 6 X 6=252 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX27 [Title/Abstract] AND ATP9A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EB-A5VU-01A | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000484427 | ENST00000311637 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| 3UTR-3CDS | ENST00000484427 | ENST00000338821 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| 3UTR-3CDS | ENST00000484427 | ENST00000402822 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| 3UTR-intron | ENST00000484427 | ENST00000477492 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| Frame-shift | ENST00000371764 | ENST00000311637 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| Frame-shift | ENST00000371764 | ENST00000338821 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| Frame-shift | ENST00000371764 | ENST00000402822 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
| 5CDS-intron | ENST00000371764 | ENST00000477492 | DDX27 | chr20 | 47836078 | + | ATP9A | chr20 | 50286648 | - |
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FusionProtFeatures for DDX27_ATP9A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX27 | ATP9A |