|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9543 |
FusionGeneSummary for DDT_GHRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDT_GHRL | Fusion gene ID: 9543 | Hgene | Tgene | Gene symbol | DDT | GHRL | Gene ID | 1652 | 51738 |
| Gene name | D-dopachrome tautomerase | ghrelin and obestatin prepropeptide | |
| Synonyms | D-DT|DDCT|MIF-2|MIF2 | MTLRP | |
| Cytomap | 22q11.23 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-dopachrome decarboxylasephenylpyruvate tautomerase II | appetite-regulating hormoneIn2c-preproghrelinghrelin, growth hormone secretagogue receptor ligandghrelin/obestatin preprohormoneghrelin/obestatin prepropeptidegrowth hormone-releasing peptidemotilin-related peptideprepro-appetite regulatory hormone | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P30046 | Q9UBU3 | |
| Ensembl transtripts involved in fusion gene | ENST00000398344, ENST00000350608, ENST00000404092, ENST00000403754, ENST00000430101, | ENST00000335542, ENST00000430179, ENST00000422159, ENST00000450603, ENST00000449554, ENST00000446937, ENST00000457360, ENST00000437422, ENST00000439975, ENST00000287656, ENST00000449238, ENST00000429122, ENST00000476283, | |
| Fusion gene scores | * DoF score | 6 X 2 X 4=48 | 3 X 2 X 2=12 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DDT [Title/Abstract] AND GHRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDT | GO:0010760 | negative regulation of macrophage chemotaxis | 21817065 |
| Hgene | DDT | GO:0032760 | positive regulation of tumor necrosis factor production | 21817065 |
| Tgene | GHRL | GO:0001937 | negative regulation of endothelial cell proliferation | 15572208 |
| Tgene | GHRL | GO:0008154 | actin polymerization or depolymerization | 15232612 |
| Tgene | GHRL | GO:0009725 | response to hormone | 15232612 |
| Tgene | GHRL | GO:0016358 | dendrite development | 16491079 |
| Tgene | GHRL | GO:0032691 | negative regulation of interleukin-1 beta production | 15232612 |
| Tgene | GHRL | GO:0042127 | regulation of cell proliferation | 15564328|16394173 |
| Tgene | GHRL | GO:0042322 | negative regulation of circadian sleep/wake cycle, REM sleep | 18329818 |
| Tgene | GHRL | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 15232612 |
| Tgene | GHRL | GO:0043066 | negative regulation of apoptotic process | 15158140 |
| Tgene | GHRL | GO:0043627 | response to estrogen | 15292338 |
| Tgene | GHRL | GO:0045409 | negative regulation of interleukin-6 biosynthetic process | 15232612 |
| Tgene | GHRL | GO:0046010 | positive regulation of circadian sleep/wake cycle, non-REM sleep | 18329818 |
| Tgene | GHRL | GO:0046697 | decidualization | 17494105 |
| Tgene | GHRL | GO:0050728 | negative regulation of inflammatory response | 15232612 |
| Tgene | GHRL | GO:0051461 | positive regulation of corticotropin secretion | 12566947 |
| Tgene | GHRL | GO:0051464 | positive regulation of cortisol secretion | 12566947|18329818 |
| Tgene | GHRL | GO:0051965 | positive regulation of synapse assembly | 16491079 |
| Tgene | GHRL | GO:0060124 | positive regulation of growth hormone secretion | 12566947|18329818 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-PG-A915-01A | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000398344 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000398344 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000398344 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000350608 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000350608 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000350608 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000404092 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000404092 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000404092 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000403754 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000403754 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000403754 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000430101 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000430101 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000430101 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
Top |
FusionProtFeatures for DDT_GHRL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDT | GHRL |