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Fusion gene ID: 9480 |
FusionGeneSummary for DCUN1D4_PTPRT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DCUN1D4_PTPRT | Fusion gene ID: 9480 | Hgene | Tgene | Gene symbol | DCUN1D4 | PTPRT | Gene ID | 23142 | 11122 |
| Gene name | defective in cullin neddylation 1 domain containing 4 | protein tyrosine phosphatase, receptor type T | |
| Synonyms | - | RPTPrho | |
| Cytomap | 4q12 | 20q12-q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4 | receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q92564 | O14522 | |
| Ensembl transtripts involved in fusion gene | ENST00000381441, ENST00000334635, ENST00000513800, ENST00000381437, ENST00000451288, | ENST00000373184, ENST00000373187, ENST00000356100, ENST00000373190, ENST00000373193, ENST00000373198, ENST00000373201, ENST00000485499, | |
| Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 10 X 8 X 6=480 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DCUN1D4 [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPRT | GO:0006470 | protein dephosphorylation | 16973135 |
| Tgene | PTPRT | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 18644975 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A1Q9-06A | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000381441 | ENST00000373184 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000373187 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000356100 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000373190 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000373193 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000373198 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000381441 | ENST00000373201 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-intron | ENST00000381441 | ENST00000485499 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373184 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373187 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000356100 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373190 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373193 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373198 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000334635 | ENST00000373201 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| 5CDS-intron | ENST00000334635 | ENST00000485499 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373184 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373187 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000356100 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373190 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373193 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373198 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-3CDS | ENST00000513800 | ENST00000373201 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| intron-intron | ENST00000513800 | ENST00000485499 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373184 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373187 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000356100 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373190 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373193 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373198 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000381437 | ENST00000373201 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| 5CDS-intron | ENST00000381437 | ENST00000485499 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373184 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373187 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000356100 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373190 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373193 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373198 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| Frame-shift | ENST00000451288 | ENST00000373201 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
| 5CDS-intron | ENST00000451288 | ENST00000485499 | DCUN1D4 | chr4 | 52777340 | + | PTPRT | chr20 | 41101202 | - |
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FusionProtFeatures for DCUN1D4_PTPRT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DCUN1D4 | PTPRT |