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Fusion gene ID: 9443 |
FusionGeneSummary for DCPS_TIRAP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DCPS_TIRAP | Fusion gene ID: 9443 | Hgene | Tgene | Gene symbol | DCPS | TIRAP | Gene ID | 28960 | 114609 |
| Gene name | decapping enzyme, scavenger | TIR domain containing adaptor protein | |
| Synonyms | ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015 | BACTS1|Mal|MyD88-2|wyatt | |
| Cytomap | 11q24.2 | 11q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | m7GpppX diphosphatase5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatasedecapping scavenger enzymeheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding protein 5histidine triad protein member 5ho | toll/interleukin-1 receptor domain-containing adapter proteinMyD88 adapter-like proteinToll-like receptor adaptor proteinadapter protein wyattadaptor protein Wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96C86 | P58753 | |
| Ensembl transtripts involved in fusion gene | ENST00000263579, ENST00000530860, | ENST00000392679, ENST00000467006, ENST00000392678, ENST00000392680, | |
| Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DCPS [Title/Abstract] AND TIRAP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DCPS | GO:0036245 | cellular response to menadione | 16140270 |
| Hgene | DCPS | GO:0043069 | negative regulation of programmed cell death | 16140270 |
| Hgene | DCPS | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
| Tgene | TIRAP | GO:0032496 | response to lipopolysaccharide | 11544529 |
| Tgene | TIRAP | GO:0032738 | positive regulation of interleukin-15 production | 18583567 |
| Tgene | TIRAP | GO:0035665 | TIRAP-dependent toll-like receptor 4 signaling pathway | 11544529 |
| Tgene | TIRAP | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15294994 |
| Tgene | TIRAP | GO:0090073 | positive regulation of protein homodimerization activity | 12062447 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A195-06A | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000263579 | ENST00000392679 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-3UTR | ENST00000263579 | ENST00000467006 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-5UTR | ENST00000263579 | ENST00000392678 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-5UTR | ENST00000263579 | ENST00000392680 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392679 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-3UTR | ENST00000530860 | ENST00000467006 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392678 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392680 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
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FusionProtFeatures for DCPS_TIRAP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DCPS | TIRAP |