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Fusion gene ID: 9388

FusionGeneSummary for DCAF8_AIG1

Fusion gene summary

Fusion gene information	Fusion gene name: DCAF8_AIG1
	Fusion gene ID: 9388
		Hgene	Tgene
	Gene symbol	DCAF8	AIG1
	Gene ID	50717	51390
	Gene name	DDB1 and CUL4 associated factor 8	androgen induced 1
	Synonyms	GAN2\|H326\|WDR42A	AIG-1\|dJ95L4.1
	Cytomap	1q23.2	6q24.2
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 8WD repeat domain 42AWD repeat-containing protein 42A	androgen-induced gene 1 protein
	Modification date	20180519	20180529
	UniProtAcc	Q5TAQ9	Q9NVV5
	Ensembl transtripts involved in fusion gene	ENST00000368073, ENST00000326837, ENST00000368074, ENST00000608310, ENST00000556710, ENST00000610139, ENST00000475733,	ENST00000357847, ENST00000344492, ENST00000275235, ENST00000367598, ENST00000494282, ENST00000367596,
Fusion gene scores	* DoF score	8 X 9 X 5=360	6 X 4 X 5=120
	# samples	13	7
	** MAII score	log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DCAF8 [Title/Abstract] AND AIG1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-EB-A6L9-06A	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000368073	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368073	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368073	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368073	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368073	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-intron	ENST00000368073	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000326837	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000326837	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000326837	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000326837	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000326837	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-intron	ENST00000326837	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368074	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368074	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368074	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368074	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000368074	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-intron	ENST00000368074	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000608310	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000608310	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000608310	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000608310	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000608310	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-intron	ENST00000608310	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000556710	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000556710	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000556710	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000556710	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-3CDS	ENST00000556710	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
5UTR-intron	ENST00000556710	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000610139	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000610139	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000610139	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000610139	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000610139	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-intron	ENST00000610139	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000475733	ENST00000357847	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000475733	ENST00000344492	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000475733	ENST00000275235	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000475733	ENST00000367598	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-3CDS	ENST00000475733	ENST00000494282	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+
intron-intron	ENST00000475733	ENST00000367596	DCAF8	chr1	160252734	-	AIG1	chr6	143486219	+

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FusionProtFeatures for DCAF8_AIG1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF8 Q5TAQ9	AIG1 Q9NVV5

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Fusion gene ID: 9388

FusionGeneSummary for DCAF8_AIG1

FusionProtFeatures for DCAF8_AIG1