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Fusion gene ID: 9311 |
FusionGeneSummary for DARS_DARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DARS_DARS | Fusion gene ID: 9311 | Hgene | Tgene | Gene symbol | DARS | DARS | Gene ID | 1615 | 1615 |
| Gene name | aspartyl-tRNA synthetase | aspartyl-tRNA synthetase | |
| Synonyms | HBSL|aspRS | HBSL|aspRS | |
| Cytomap | 2q21.3 | 2q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aspartate--tRNA ligase, cytoplasmicaspartate tRNA ligase 1, cytoplasmicaspartyl-tRNA synthetase, cytoplasmiccell proliferation-inducing gene 40 proteintesticular tissue protein Li 192 | aspartate--tRNA ligase, cytoplasmicaspartate tRNA ligase 1, cytoplasmicaspartyl-tRNA synthetase, cytoplasmiccell proliferation-inducing gene 40 proteintesticular tissue protein Li 192 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P14868 | P14868 | |
| Ensembl transtripts involved in fusion gene | ENST00000264161, ENST00000537273, ENST00000463008, | ENST00000264161, ENST00000537273, ENST00000463008, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 4 X 4 X 3=48 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/50*10)=0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DARS [Title/Abstract] AND DARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI393124 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000264161 | ENST00000264161 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000264161 | ENST00000537273 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000264161 | ENST00000463008 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000537273 | ENST00000264161 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000537273 | ENST00000537273 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000537273 | ENST00000463008 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000463008 | ENST00000264161 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000463008 | ENST00000537273 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
| intron-intron | ENST00000463008 | ENST00000463008 | DARS | chr2 | 136672907 | + | DARS | chr2 | 136671520 | + |
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FusionProtFeatures for DARS_DARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DARS | DARS |