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Fusion gene ID: 931 |
FusionGeneSummary for ADNP_ZNF841 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADNP_ZNF841 | Fusion gene ID: 931 | Hgene | Tgene | Gene symbol | ADNP | ZNF841 | Gene ID | 23394 | 284371 |
| Gene name | activity dependent neuroprotector homeobox | zinc finger protein 841 | |
| Synonyms | ADNP1|HVDAS|MRD28 | - | |
| Cytomap | 20q13.13 | 19q13.41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | activity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotector | zinc finger protein 841 | |
| Modification date | 20180522 | 20180403 | |
| UniProtAcc | Q9H2P0 | Q6ZN19 | |
| Ensembl transtripts involved in fusion gene | ENST00000396029, ENST00000396032, ENST00000371602, ENST00000349014, | ENST00000594295, ENST00000426391, ENST00000389534, ENST00000359973, | |
| Fusion gene scores | * DoF score | 13 X 4 X 9=468 | 2 X 2 X 2=8 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/468*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ADNP [Title/Abstract] AND ZNF841 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XD-01A | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000396029 | ENST00000594295 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| 5UTR-5UTR | ENST00000396029 | ENST00000426391 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| 5UTR-5UTR | ENST00000396029 | ENST00000389534 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| 5UTR-intron | ENST00000396029 | ENST00000359973 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-3CDS | ENST00000396032 | ENST00000594295 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000396032 | ENST00000426391 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000396032 | ENST00000389534 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-intron | ENST00000396032 | ENST00000359973 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-3CDS | ENST00000371602 | ENST00000594295 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000371602 | ENST00000426391 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000371602 | ENST00000389534 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-intron | ENST00000371602 | ENST00000359973 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-3CDS | ENST00000349014 | ENST00000594295 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000349014 | ENST00000426391 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-5UTR | ENST00000349014 | ENST00000389534 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
| intron-intron | ENST00000349014 | ENST00000359973 | ADNP | chr20 | 49545188 | - | ZNF841 | chr19 | 52570863 | - |
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FusionProtFeatures for ADNP_ZNF841 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADNP | ZNF841 |