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Fusion gene ID: 9246 |
FusionGeneSummary for DAB2_SERPINB6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAB2_SERPINB6 | Fusion gene ID: 9246 | Hgene | Tgene | Gene symbol | DAB2 | SERPINB6 | Gene ID | 1601 | 5269 |
| Gene name | DAB2, clathrin adaptor protein | serpin family B member 6 | |
| Synonyms | DOC-2|DOC2 | CAP|DFNB91|MSTP057|PI-6|PI6|PTI|SPI3 | |
| Cytomap | 5p13.1 | 6p25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disabled homolog 2Dab, mitogen-responsive phosphoprotein, homolog 2adaptor molecule disabled-2differentially expressed in ovarian carcinoma 2differentially-expressed protein 2disabled homolog 2, mitogen-responsive phosphoprotein | serpin B6cytoplasmic antiproteinaseprotease inhibitor 6 (placental thrombin inhibitor)serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6serpin peptidase inhibitor, clade B (ovalbumin), member 6 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P98082 | P35237 | |
| Ensembl transtripts involved in fusion gene | ENST00000339788, ENST00000320816, ENST00000545653, ENST00000509337, ENST00000512525, | ENST00000380520, ENST00000380524, ENST00000380529, ENST00000380539, ENST00000380546, ENST00000335686, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 6 X 7 X 4=168 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DAB2 [Title/Abstract] AND SERPINB6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DAB2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 15734730 |
| Hgene | DAB2 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 11387212 |
| Hgene | DAB2 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 11387212 |
| Hgene | DAB2 | GO:0043066 | negative regulation of apoptotic process | 15734730 |
| Hgene | DAB2 | GO:0060391 | positive regulation of SMAD protein signal transduction | 11387212 |
| Tgene | SERPINB6 | GO:0010951 | negative regulation of endopeptidase activity | 17761692 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | S69272 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000339788 | ENST00000380520 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000339788 | ENST00000380524 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000339788 | ENST00000380529 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000339788 | ENST00000380539 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000339788 | ENST00000380546 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000339788 | ENST00000335686 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000380520 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000380524 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000380529 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000380539 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000380546 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000320816 | ENST00000335686 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000380520 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000380524 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000380529 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000380539 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000380546 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000545653 | ENST00000335686 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000380520 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000380524 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000380529 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000380539 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000380546 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000509337 | ENST00000335686 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000380520 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000380524 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000380529 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000380539 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000380546 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
| intron-5UTR | ENST00000512525 | ENST00000335686 | DAB2 | chr5 | 39462178 | - | SERPINB6 | chr6 | 2959578 | - |
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FusionProtFeatures for DAB2_SERPINB6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAB2 | SERPINB6 |