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Fusion gene ID: 9233 |
FusionGeneSummary for DAB1_PMP22 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAB1_PMP22 | Fusion gene ID: 9233 | Hgene | Tgene | Gene symbol | DAB1 | PMP22 | Gene ID | 115209 | 5376 |
| Gene name | OMA1 zinc metallopeptidase | peripheral myelin protein 22 | |
| Synonyms | 2010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase | CIDP|CMT1A|CMT1E|DSS|GAS-3|GAS3|HMSNIA|HNPP|Sp110 | |
| Cytomap | 1p32.2-p32.1 | 17p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase | peripheral myelin protein 22growth arrest-specific protein 3peripheral myelin protein 22 kDa | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O75553 | Q01453 | |
| Ensembl transtripts involved in fusion gene | ENST00000485760, ENST00000371236, ENST00000371234, ENST00000420954, ENST00000439789, ENST00000414851, ENST00000371231, ENST00000371230, | ENST00000395938, ENST00000312280, ENST00000494511, ENST00000395936, ENST00000426385, | |
| Fusion gene scores | * DoF score | 10 X 9 X 3=270 | 5 X 5 X 2=50 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: DAB1 [Title/Abstract] AND PMP22 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PMP22 | GO:0008219 | cell death | 12107182 |
| Tgene | PMP22 | GO:0032060 | bleb assembly | 12107182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM720166 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000485760 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000485760 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000485760 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000485760 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000485760 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371236 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371236 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371236 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371236 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371236 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371234 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371234 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371234 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371234 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371234 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000420954 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000420954 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000420954 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000420954 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000420954 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000439789 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000439789 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000439789 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000439789 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000439789 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000414851 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000414851 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000414851 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000414851 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000414851 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371231 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371231 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371231 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371231 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371231 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371230 | ENST00000395938 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371230 | ENST00000312280 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371230 | ENST00000494511 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371230 | ENST00000395936 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
| intron-3CDS | ENST00000371230 | ENST00000426385 | DAB1 | chr1 | 58853266 | - | PMP22 | chr17 | 15142860 | - |
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FusionProtFeatures for DAB1_PMP22 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAB1 | PMP22 |