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Fusion gene ID: 9178 |
FusionGeneSummary for CYP4Z1_ALYREF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP4Z1_ALYREF | Fusion gene ID: 9178 | Hgene | Tgene | Gene symbol | CYP4Z1 | ALYREF | Gene ID | 199974 | 10189 |
| Gene name | cytochrome P450 family 4 subfamily Z member 1 | Aly/REF export factor | |
| Synonyms | CYP4A20 | ALY|ALY/REF|BEF|REF|THOC4 | |
| Cytomap | 1p33 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome P450 4Z1CYPIVZ1cytochrome P450, family 4, subfamily Z, polypeptide 1 | THO complex subunit 4THO complex 4ally of AML-1 and LEF-1bZIP enhancing factorbZIP-enhancing factor BEFtho4transcriptional coactivator Aly/REF | |
| Modification date | 20180331 | 20180522 | |
| UniProtAcc | Q86W10 | Q86V81 | |
| Ensembl transtripts involved in fusion gene | ENST00000334194, ENST00000471598, | ENST00000331204, ENST00000505490, ENST00000512673, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: CYP4Z1 [Title/Abstract] AND ALYREF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ALYREF | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-A3KG-01A | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000334194 | ENST00000331204 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| Frame-shift | ENST00000334194 | ENST00000505490 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| 5CDS-5UTR | ENST00000334194 | ENST00000512673 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-3CDS | ENST00000471598 | ENST00000331204 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-3CDS | ENST00000471598 | ENST00000505490 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-5UTR | ENST00000471598 | ENST00000512673 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
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FusionProtFeatures for CYP4Z1_ALYREF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP4Z1 | ALYREF |