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Fusion gene ID: 917 |
FusionGeneSummary for ADNP2_PARD6G |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADNP2_PARD6G | Fusion gene ID: 917 | Hgene | Tgene | Gene symbol | ADNP2 | PARD6G | Gene ID | 22850 | 84552 |
| Gene name | ADNP homeobox 2 | par-6 family cell polarity regulator gamma | |
| Synonyms | ZNF508 | PAR-6G|PAR6gamma | |
| Cytomap | 18q23 | 18q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | activity-dependent neuroprotector homeobox protein 2ADNP homeobox protein 2zinc finger protein 508 | partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6IQ32 | Q9BYG4 | |
| Ensembl transtripts involved in fusion gene | ENST00000262198, | ENST00000353265, ENST00000470488, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 7 X 2 X 7=98 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADNP2 [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-CS-5393-01A | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000262198 | ENST00000353265 | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
| 5UTR-3CDS | ENST00000262198 | ENST00000470488 | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
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FusionProtFeatures for ADNP2_PARD6G |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADNP2 | PARD6G |