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Fusion gene ID: 9161 |
FusionGeneSummary for CYP2E1_REG3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP2E1_REG3A | Fusion gene ID: 9161 | Hgene | Tgene | Gene symbol | CYP2E1 | REG3A | Gene ID | 1571 | 5068 |
| Gene name | cytochrome P450 family 2 subfamily E member 1 | regenerating family member 3 alpha | |
| Synonyms | CPE1|CYP2E|P450-J|P450C2E | HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3 | |
| Cytomap | 10q26.3 | 2p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome P450 2E14-nitrophenol 2-hydroxylaseCYPIIE1cytochrome P450, family 2, subfamily E, polypeptide 1cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1cytochrome P450-Jflavoprotein-linked monooxygenasemicrosomal monooxygenasexe | regenerating islet-derived protein 3-alphaPAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation- | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P05181 | Q06141 | |
| Ensembl transtripts involved in fusion gene | ENST00000463117, ENST00000252945, ENST00000480558, | ENST00000409839, ENST00000393878, ENST00000305165, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 2=32 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYP2E1 [Title/Abstract] AND REG3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CYP2E1 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
| Hgene | CYP2E1 | GO:0017144 | drug metabolic process | 19219744 |
| Hgene | CYP2E1 | GO:0046483 | heterocycle metabolic process | 19651758 |
| Hgene | CYP2E1 | GO:0055114 | oxidation-reduction process | 16401082|19219744 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A4NP-01A | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000463117 | ENST00000409839 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| In-frame | ENST00000463117 | ENST00000393878 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| In-frame | ENST00000463117 | ENST00000305165 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| In-frame | ENST00000252945 | ENST00000409839 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| In-frame | ENST00000252945 | ENST00000393878 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| In-frame | ENST00000252945 | ENST00000305165 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| intron-3CDS | ENST00000480558 | ENST00000409839 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| intron-3CDS | ENST00000480558 | ENST00000393878 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
| intron-3CDS | ENST00000480558 | ENST00000305165 | CYP2E1 | chr10 | 135341076 | + | REG3A | chr2 | 79384824 | - |
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FusionProtFeatures for CYP2E1_REG3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP2E1 | REG3A |