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Fusion gene ID: 9117

FusionGeneSummary for CYC1_FGA

Fusion gene summary

Fusion gene information	Fusion gene name: CYC1_FGA
	Fusion gene ID: 9117
		Hgene	Tgene
	Gene symbol	CYC1	FGA
	Gene ID	10983	2243
	Gene name	cyclin I	fibrinogen alpha chain
	Synonyms	CCNI1\|CYC1\|CYI	Fib2
	Cytomap	4q21.1	4q31.3
	Type of gene	protein-coding	protein-coding
	Description	cyclin-Icyclin ITI	fibrinogen alpha chainfibrinogen, A alpha polypeptide
	Modification date	20180523	20180520
	UniProtAcc	P08574	P02671
	Ensembl transtripts involved in fusion gene	ENST00000318911,	ENST00000302053, ENST00000403106,
Fusion gene scores	* DoF score	5 X 5 X 4=100	3 X 3 X 2=18
	# samples	5	3
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CYC1 [Title/Abstract] AND FGA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FGA	GO:0007160	cell-matrix adhesion	10903502
Tgene	FGA	GO:0031639	plasminogen activation	16846481
Tgene	FGA	GO:0034116	positive regulation of heterotypic cell-cell adhesion	8100742
Tgene	FGA	GO:0034622	cellular protein-containing complex assembly	8910396
Tgene	FGA	GO:0042730	fibrinolysis	16846481
Tgene	FGA	GO:0043152	induction of bacterial agglutination	24367264
Tgene	FGA	GO:0045907	positive regulation of vasoconstriction	15739255
Tgene	FGA	GO:0045921	positive regulation of exocytosis	19193866
Tgene	FGA	GO:0050714	positive regulation of protein secretion	19193866
Tgene	FGA	GO:0051258	protein polymerization	12706644
Tgene	FGA	GO:0051592	response to calcium ion	6777381
Tgene	FGA	GO:0070374	positive regulation of ERK1 and ERK2 cascade	10903502\|19193866
Tgene	FGA	GO:0070527	platelet aggregation	6281794
Tgene	FGA	GO:0072378	blood coagulation, fibrin clot formation	16846481
Tgene	FGA	GO:0090277	positive regulation of peptide hormone secretion	19193866
Tgene	FGA	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	10903502
Tgene	FGA	GO:2000352	negative regulation of endothelial cell apoptotic process	10903502

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LIHC	TCGA-ZP-A9D0-01A	CYC1	chr8	145151153	+	FGA	chr4	155508070	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000318911	ENST00000302053	CYC1	chr8	145151153	+	FGA	chr4	155508070	-
Frame-shift	ENST00000318911	ENST00000403106	CYC1	chr8	145151153	+	FGA	chr4	155508070	-

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FusionProtFeatures for CYC1_FGA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYC1 P08574	FGA P02671

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Fusion gene ID: 9117

FusionGeneSummary for CYC1_FGA

FusionProtFeatures for CYC1_FGA