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Fusion gene ID: 9114 |
FusionGeneSummary for CYBRD1_SLC38A11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYBRD1_SLC38A11 | Fusion gene ID: 9114 | Hgene | Tgene | Gene symbol | CYBRD1 | SLC38A11 | Gene ID | 79901 | 151258 |
| Gene name | cytochrome b reductase 1 | solute carrier family 38 member 11 | |
| Synonyms | CYB561A2|DCYTB|FRRS3 | AVT2 | |
| Cytomap | 2q31.1 | 2q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome b reductase 1cytochrome b561 family, member A2duodenal cytochrome bferric-chelate reductase 3 | putative sodium-coupled neutral amino acid transporter 11 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q53TN4 | Q08AI6 | |
| Ensembl transtripts involved in fusion gene | ENST00000409484, ENST00000468308, ENST00000321348, ENST00000375252, | ENST00000303735, ENST00000409149, ENST00000409058, ENST00000409662, ENST00000493887, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 5 X 4 X 6=120 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYBRD1 [Title/Abstract] AND SLC38A11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A25B-01A | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000409484 | ENST00000303735 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| intron-3CDS | ENST00000409484 | ENST00000409149 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| intron-3CDS | ENST00000409484 | ENST00000409058 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| intron-3CDS | ENST00000409484 | ENST00000409662 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| intron-5UTR | ENST00000409484 | ENST00000493887 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 3UTR-3CDS | ENST00000468308 | ENST00000303735 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 3UTR-3CDS | ENST00000468308 | ENST00000409149 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 3UTR-3CDS | ENST00000468308 | ENST00000409058 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 3UTR-3CDS | ENST00000468308 | ENST00000409662 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 3UTR-5UTR | ENST00000468308 | ENST00000493887 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000321348 | ENST00000303735 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000321348 | ENST00000409149 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000321348 | ENST00000409058 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000321348 | ENST00000409662 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 5CDS-5UTR | ENST00000321348 | ENST00000493887 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000375252 | ENST00000303735 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000375252 | ENST00000409149 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000375252 | ENST00000409058 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| Frame-shift | ENST00000375252 | ENST00000409662 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
| 5CDS-5UTR | ENST00000375252 | ENST00000493887 | CYBRD1 | chr2 | 172379248 | + | SLC38A11 | chr2 | 165772483 | - |
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FusionProtFeatures for CYBRD1_SLC38A11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYBRD1 | SLC38A11 |