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Fusion gene ID: 9112 |
FusionGeneSummary for CYBB_ADAM10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYBB_ADAM10 | Fusion gene ID: 9112 | Hgene | Tgene | Gene symbol | CYBB | ADAM10 | Gene ID | 1536 | 102 |
| Gene name | cytochrome b-245 beta chain | ADAM metallopeptidase domain 10 | |
| Synonyms | AMCBX2|CGD|GP91-1|GP91-PHOX|GP91PHOX|IMD34|NOX2|p91-PHOX | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | |
| Cytomap | Xp21.1-p11.4 | 15q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome b-245 heavy chainCGD91-phoxNADPH oxidase 2cytochrome b(558) subunit betacytochrome b-245 beta polypeptidecytochrome b558 subunit betaheme-binding membrane glycoprotein gp91phoxneutrophil cytochrome b 91 kDa polypeptidep22 phagocyte B-cy | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P04839 | O14672 | |
| Ensembl transtripts involved in fusion gene | ENST00000378588, ENST00000545017, ENST00000536160, ENST00000492288, | ENST00000260408, ENST00000402627, ENST00000561288, ENST00000396140, ENST00000558733, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYBB [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CYBB | GO:0006801 | superoxide metabolic process | 12042318 |
| Hgene | CYBB | GO:0042554 | superoxide anion generation | 12042318 |
| Hgene | CYBB | GO:0055114 | oxidation-reduction process | 12042318 |
| Tgene | ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
| Tgene | ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
| Tgene | ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
| Tgene | ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | Z48614 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000378588 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000378588 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000378588 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000378588 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000378588 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-3CDS | ENST00000545017 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000545017 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000545017 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000545017 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000545017 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-3CDS | ENST00000536160 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000536160 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000536160 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000536160 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000536160 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-3CDS | ENST00000492288 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000492288 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000492288 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000492288 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
| intron-intron | ENST00000492288 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
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FusionProtFeatures for CYBB_ADAM10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYBB | ADAM10 |