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Fusion gene ID: 9109 |
FusionGeneSummary for CYBA_CYBA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYBA_CYBA | Fusion gene ID: 9109 | Hgene | Tgene | Gene symbol | CYBA | CYBA | Gene ID | 1535 | 1535 |
| Gene name | cytochrome b-245 alpha chain | cytochrome b-245 alpha chain | |
| Synonyms | p22-PHOX | p22-PHOX | |
| Cytomap | 16q24.2 | 16q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptiden | cytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptiden | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P13498 | P13498 | |
| Ensembl transtripts involved in fusion gene | ENST00000261623, ENST00000567174, ENST00000569359, ENST00000561972, | ENST00000261623, ENST00000567174, ENST00000569359, ENST00000561972, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CYBA [Title/Abstract] AND CYBA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CYBA | GO:0017004 | cytochrome complex assembly | 7938008 |
| Hgene | CYBA | GO:0032755 | positive regulation of interleukin-6 production | 22423966 |
| Hgene | CYBA | GO:0032760 | positive regulation of tumor necrosis factor production | 22423966 |
| Hgene | CYBA | GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway | 22423966 |
| Hgene | CYBA | GO:0050766 | positive regulation of phagocytosis | 22423966 |
| Hgene | CYBA | GO:1900426 | positive regulation of defense response to bacterium | 22423966 |
| Hgene | CYBA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 22423966 |
| Tgene | CYBA | GO:0017004 | cytochrome complex assembly | 7938008 |
| Tgene | CYBA | GO:0032755 | positive regulation of interleukin-6 production | 22423966 |
| Tgene | CYBA | GO:0032760 | positive regulation of tumor necrosis factor production | 22423966 |
| Tgene | CYBA | GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway | 22423966 |
| Tgene | CYBA | GO:0050766 | positive regulation of phagocytosis | 22423966 |
| Tgene | CYBA | GO:1900426 | positive regulation of defense response to bacterium | 22423966 |
| Tgene | CYBA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 22423966 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW374327 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000261623 | ENST00000261623 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000261623 | ENST00000567174 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000261623 | ENST00000569359 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-intron | ENST00000261623 | ENST00000561972 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000567174 | ENST00000261623 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000567174 | ENST00000567174 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000567174 | ENST00000569359 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-intron | ENST00000567174 | ENST00000561972 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000569359 | ENST00000261623 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000569359 | ENST00000567174 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000569359 | ENST00000569359 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-intron | ENST00000569359 | ENST00000561972 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000561972 | ENST00000261623 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000561972 | ENST00000567174 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-3CDS | ENST00000561972 | ENST00000569359 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
| intron-intron | ENST00000561972 | ENST00000561972 | CYBA | chr16 | 88712577 | - | CYBA | chr16 | 88713562 | - |
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FusionProtFeatures for CYBA_CYBA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYBA | CYBA |