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Fusion gene ID: 9089

FusionGeneSummary for CYB561_PSPH

Fusion gene summary

Fusion gene information	Fusion gene name: CYB561_PSPH
	Fusion gene ID: 9089
		Hgene	Tgene
	Gene symbol	CYB561	PSPH
	Gene ID	1534	5723
	Gene name	cytochrome b561	phosphoserine phosphatase
	Synonyms	CYB561A1\|FRRS2	PSP\|PSPHD
	Cytomap	17q23.3	7p11.2
	Type of gene	protein-coding	protein-coding
	Description	cytochrome b561cytochrome b-561cytochrome b561 family, member A1ferric-chelate reductase 2	phosphoserine phosphataseL-3-phosphoserine phosphataseO-phosphoserine phosphohydrolasePSPase
	Modification date	20180523	20180523
	UniProtAcc	P49447	P78330
	Ensembl transtripts involved in fusion gene	ENST00000392975, ENST00000360793, ENST00000584031, ENST00000392976, ENST00000582297, ENST00000581573, ENST00000448884, ENST00000582034, ENST00000542042, ENST00000581163, ENST00000582997,	ENST00000275605, ENST00000395471, ENST00000459834,
Fusion gene scores	* DoF score	10 X 6 X 5=300	12 X 13 X 4=624
	# samples	11	14
	** MAII score	log2(11/300*10)=-1.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/624*10)=-2.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CYB561 [Title/Abstract] AND PSPH [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PSPH	GO:0006563	L-serine metabolic process	15291819

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BI199927	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
ChiTaRS3.1			BF314617	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000392975	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000392975	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000392975	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000360793	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000360793	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000360793	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000584031	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000584031	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000584031	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000392976	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000392976	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000392976	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582297	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582297	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582297	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581573	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581573	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581573	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000448884	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000448884	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000448884	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582034	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582034	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582034	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000542042	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000542042	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000542042	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581163	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581163	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000581163	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582997	ENST00000275605	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582997	ENST00000395471	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+
intron-intron	ENST00000582997	ENST00000459834	CYB561	chr17	61513478	-	PSPH	chr7	56119538	+

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FusionProtFeatures for CYB561_PSPH

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYB561 P49447	PSPH P78330

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Fusion gene ID: 9089

FusionGeneSummary for CYB561_PSPH

FusionProtFeatures for CYB561_PSPH