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Fusion gene ID: 9070 |
FusionGeneSummary for CXCR4_TSC22D3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CXCR4_TSC22D3 | Fusion gene ID: 9070 | Hgene | Tgene | Gene symbol | CXCR4 | TSC22D3 | Gene ID | 7852 | 1831 |
| Gene name | C-X-C motif chemokine receptor 4 | TSC22 domain family member 3 | |
| Synonyms | CD184|D2S201E|FB22|HM89|HSY3RR|LAP-3|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R|WHIM|WHIMS | DIP|DSIPI|GILZ|TSC-22R | |
| Cytomap | 2q22.1 | Xq22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-X-C chemokine receptor type 4CD184 antigenLPS-associated protein 3SDF-1 receptorchemokine (C-X-C motif) receptor 4chemokine receptorfusinleukocyte-derived seven transmembrane domain receptorlipopolysaccharide-associated protein 3neuropeptide Y | TSC22 domain family protein 3DSIP-immunoreactive leucine zipper proteinDSIP-immunoreactive peptideTSC-22 related proteinTSC-22-like proteindelta sleep-inducing peptide immunoreactorglucocorticoid-induced leucine zipper protein | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P61073 | Q99576 | |
| Ensembl transtripts involved in fusion gene | ENST00000409817, ENST00000241393, ENST00000466288, | ENST00000372390, ENST00000372397, ENST00000315660, ENST00000372383, ENST00000372384, ENST00000372382, ENST00000506081, ENST00000514426, | |
| Fusion gene scores | * DoF score | 3 X 1 X 2=6 | 4 X 4 X 2=32 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CXCR4 [Title/Abstract] AND TSC22D3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CXCR4 | GO:0007186 | G-protein coupled receptor signaling pathway | 10644702 |
| Hgene | CXCR4 | GO:0071345 | cellular response to cytokine stimulus | 21540189 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CT004483 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000409817 | ENST00000372390 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000372397 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000315660 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000372383 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000372384 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000372382 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000506081 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000409817 | ENST00000514426 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000372390 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000372397 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000315660 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000372383 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000372384 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000372382 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000506081 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| 5CDS-5UTR | ENST00000241393 | ENST00000514426 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000372390 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000372397 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000315660 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000372383 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000372384 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000372382 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000506081 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
| intron-5UTR | ENST00000466288 | ENST00000514426 | CXCR4 | chr2 | 136875616 | - | TSC22D3 | chrX | 106959180 | - |
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FusionProtFeatures for CXCR4_TSC22D3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CXCR4 | TSC22D3 |