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Fusion gene ID: 9068

FusionGeneSummary for CXCR4_CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CXCR4_CFLAR
	Fusion gene ID: 9068
		Hgene	Tgene
	Gene symbol	CXCR4	CFLAR
	Gene ID	7852	8837
	Gene name	C-X-C motif chemokine receptor 4	CASP8 and FADD like apoptosis regulator
	Synonyms	CD184\|D2S201E\|FB22\|HM89\|HSY3RR\|LAP-3\|LAP3\|LCR1\|LESTR\|NPY3R\|NPYR\|NPYRL\|NPYY3R\|WHIM\|WHIMS	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS
	Cytomap	2q22.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	C-X-C chemokine receptor type 4CD184 antigenLPS-associated protein 3SDF-1 receptorchemokine (C-X-C motif) receptor 4chemokine receptorfusinleukocyte-derived seven transmembrane domain receptorlipopolysaccharide-associated protein 3neuropeptide Y	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20180527	20180523
	UniProtAcc	P61073	O15519
	Ensembl transtripts involved in fusion gene	ENST00000409817, ENST00000241393, ENST00000466288,	ENST00000309955, ENST00000443227, ENST00000341222, ENST00000340870, ENST00000355558, ENST00000341582, ENST00000342795, ENST00000395148, ENST00000423241, ENST00000490965, ENST00000440180, ENST00000457277, ENST00000494258, ENST00000479953,
Fusion gene scores	* DoF score	3 X 1 X 2=6	9 X 6 X 6=324
	# samples	3	10
	** MAII score	log2(3/6*10)=2.32192809488736	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CXCR4 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CXCR4	GO:0007186	G-protein coupled receptor signaling pathway	10644702
Hgene	CXCR4	GO:0071345	cellular response to cytokine stimulus	21540189
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	DLBC	TCGA-FA-A6HN-01A	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000409817	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000409817	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000409817	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-5UTR	ENST00000241393	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
5CDS-intron	ENST00000241393	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000309955	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000443227	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000341222	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000340870	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000355558	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000341582	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000342795	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000395148	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000423241	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000490965	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000466288	ENST00000440180	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000457277	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000494258	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+
intron-intron	ENST00000466288	ENST00000479953	CXCR4	chr2	136875616	-	CFLAR	chr2	201994452	+

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FusionProtFeatures for CXCR4_CFLAR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CXCR4 P61073	CFLAR O15519

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Fusion gene ID: 9068

FusionGeneSummary for CXCR4_CFLAR

FusionProtFeatures for CXCR4_CFLAR