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Fusion gene ID: 9058 |
FusionGeneSummary for CXCL13_UTRN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CXCL13_UTRN | Fusion gene ID: 9058 | Hgene | Tgene | Gene symbol | CXCL13 | UTRN | Gene ID | 10563 | 7402 |
| Gene name | C-X-C motif chemokine ligand 13 | utrophin | |
| Synonyms | ANGIE|ANGIE2|BCA-1|BCA1|BLC|BLR1L|SCYB13 | DMDL|DRP|DRP1 | |
| Cytomap | 4q21.1 | 6q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-X-C motif chemokine 13B-cell chemoattractantB-cell-attracting chemokine 1B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)B-lymphocyte chemoattractantCXC chemokine BLCb cell-attracting chemokine 1b lymphocyte chemoattractantchem | utrophinDRP-1dystrophin-related protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43927 | P46939 | |
| Ensembl transtripts involved in fusion gene | ENST00000286758, | ENST00000367545, ENST00000367526, ENST00000480333, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 33 X 9 X 9=2673 |
| # samples | 1 | 33 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(33/2673*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CXCL13 [Title/Abstract] AND UTRN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CXCL13 | GO:0007166 | cell surface receptor signaling pathway | 11554781 |
| Hgene | CXCL13 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 11554781 |
| Hgene | CXCL13 | GO:0007267 | cell-cell signaling | 11554781 |
| Hgene | CXCL13 | GO:0010820 | positive regulation of T cell chemotaxis | 11554781 |
| Hgene | CXCL13 | GO:0035754 | B cell chemotaxis | 9463416 |
| Hgene | CXCL13 | GO:0035768 | endothelial cell chemotaxis to fibroblast growth factor | 11708770 |
| Hgene | CXCL13 | GO:0042742 | defense response to bacterium | 17562761 |
| Hgene | CXCL13 | GO:2000545 | negative regulation of endothelial cell chemotaxis to fibroblast growth factor | 11708770 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-85-7950-01A | CXCL13 | chr4 | 78532988 | + | UTRN | chr6 | 144665237 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000286758 | ENST00000367545 | CXCL13 | chr4 | 78532988 | + | UTRN | chr6 | 144665237 | + |
| 5CDS-intron | ENST00000286758 | ENST00000367526 | CXCL13 | chr4 | 78532988 | + | UTRN | chr6 | 144665237 | + |
| 5CDS-intron | ENST00000286758 | ENST00000480333 | CXCL13 | chr4 | 78532988 | + | UTRN | chr6 | 144665237 | + |
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FusionProtFeatures for CXCL13_UTRN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CXCL13 | UTRN |