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Fusion gene ID: 9052

FusionGeneSummary for CXADR_CXADR

Fusion gene summary

Fusion gene information	Fusion gene name: CXADR_CXADR
	Fusion gene ID: 9052
		Hgene	Tgene
	Gene symbol	CXADR	CXADR
	Gene ID	1525	1525
	Gene name	CXADR, Ig-like cell adhesion molecule	CXADR, Ig-like cell adhesion molecule
	Synonyms	CAR\|CAR4/6\|HCAR	CAR\|CAR4/6\|HCAR
	Cytomap	21q21.1	21q21.1
	Type of gene	protein-coding	protein-coding
	Description	coxsackievirus and adenovirus receptor46 kD coxsackievirus and adenovirus receptor (CAR) proteinCVB3-binding proteinHCVADRcoxsackie virus and adenovirus receptorcoxsackievirus B-adenovirus receptor	coxsackievirus and adenovirus receptor46 kD coxsackievirus and adenovirus receptor (CAR) proteinCVB3-binding proteinHCVADRcoxsackie virus and adenovirus receptorcoxsackievirus B-adenovirus receptor
	Modification date	20180519	20180519
	UniProtAcc	P78310	P78310
	Ensembl transtripts involved in fusion gene	ENST00000284878, ENST00000400166, ENST00000356275, ENST00000400165, ENST00000306618, ENST00000400169,	ENST00000284878, ENST00000400166, ENST00000356275, ENST00000400165, ENST00000306618, ENST00000400169,
Fusion gene scores	* DoF score	6 X 3 X 4=72	3 X 3 X 2=18
	# samples	5	3
	** MAII score	log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CXADR [Title/Abstract] AND CXADR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CXADR	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	12869515\|15800062
Hgene	CXADR	GO:0031532	actin cytoskeleton reorganization	17675666
Tgene	CXADR	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	12869515\|15800062
Tgene	CXADR	GO:0031532	actin cytoskeleton reorganization	17675666

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CB162053	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000284878	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000284878	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000284878	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000284878	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000284878	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000284878	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400166	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000356275	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400165	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000306618	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000284878	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000400166	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000356275	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000400165	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000306618	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+
intron-intron	ENST00000400169	ENST00000400169	CXADR	chr21	18888385	-	CXADR	chr21	18888635	+

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FusionProtFeatures for CXADR_CXADR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CXADR P78310	CXADR P78310

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Fusion gene ID: 9052

FusionGeneSummary for CXADR_CXADR

FusionProtFeatures for CXADR_CXADR