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Fusion gene ID: 9036 |
FusionGeneSummary for CWC25_FBXO47 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CWC25_FBXO47 | Fusion gene ID: 9036 | Hgene | Tgene | Gene symbol | CWC25 | FBXO47 | Gene ID | 54883 | 494188 |
| Gene name | CWC25 spliceosome associated protein homolog | F-box protein 47 | |
| Synonyms | CCDC49 | - | |
| Cytomap | 17q12 | 17q12|17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor CWC25 homologcoiled-coil domain-containing protein 49 | F-box only protein 47 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9NXE8 | Q5MNV8 | |
| Ensembl transtripts involved in fusion gene | ENST00000225428, ENST00000536127, | ENST00000378079, | |
| Fusion gene scores | * DoF score | 11 X 6 X 6=396 | 5 X 5 X 3=75 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CWC25 [Title/Abstract] AND FBXO47 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A0U3-01A | CWC25 | chr17 | 36965955 | - | FBXO47 | chr17 | 37099989 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000225428 | ENST00000378079 | CWC25 | chr17 | 36965955 | - | FBXO47 | chr17 | 37099989 | - |
| In-frame | ENST00000536127 | ENST00000378079 | CWC25 | chr17 | 36965955 | - | FBXO47 | chr17 | 37099989 | - |
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FusionProtFeatures for CWC25_FBXO47 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CWC25 | FBXO47 |