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Fusion gene ID: 9018 |
FusionGeneSummary for CUX1_MTMR7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUX1_MTMR7 | Fusion gene ID: 9018 | Hgene | Tgene | Gene symbol | CUX1 | MTMR7 | Gene ID | 1523 | 9108 |
| Gene name | cut like homeobox 1 | myotubularin related protein 7 | |
| Synonyms | CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GOLIM6|Nbla10317|p100|p110|p200|p75 | - | |
| Cytomap | 7q22.1 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein CASPCCAAT displacement proteincut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317 | myotubularin-related protein 7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13948 | Q9Y216 | |
| Ensembl transtripts involved in fusion gene | ENST00000437600, ENST00000292538, ENST00000393824, ENST00000547394, ENST00000360264, ENST00000425244, ENST00000292535, ENST00000549414, ENST00000556210, ENST00000550008, ENST00000546411, ENST00000560541, | ENST00000180173, ENST00000521857, ENST00000398099, ENST00000523571, | |
| Fusion gene scores | * DoF score | 20 X 18 X 9=3240 | 2 X 2 X 1=4 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/3240*10)=-3.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CUX1 [Title/Abstract] AND MTMR7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI732560 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000437600 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000437600 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000437600 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000437600 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292538 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292538 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292538 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292538 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000393824 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000393824 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000393824 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000393824 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000547394 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000547394 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000547394 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000547394 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000360264 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000360264 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000360264 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000360264 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000425244 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000425244 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000425244 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000425244 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292535 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292535 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292535 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000292535 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000549414 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000549414 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000549414 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000549414 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000556210 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000556210 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000556210 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000556210 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000550008 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000550008 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000550008 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000550008 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000546411 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000546411 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000546411 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000546411 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000560541 | ENST00000180173 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000560541 | ENST00000521857 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000560541 | ENST00000398099 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
| intron-intron | ENST00000560541 | ENST00000523571 | CUX1 | chr7 | 101525434 | - | MTMR7 | chr8 | 17262344 | - |
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FusionProtFeatures for CUX1_MTMR7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUX1 | MTMR7 |