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Fusion gene ID: 8962 |
FusionGeneSummary for CTU2_PRKAR2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTU2_PRKAR2A | Fusion gene ID: 8962 | Hgene | Tgene | Gene symbol | CTU2 | PRKAR2A | Gene ID | 348180 | 5576 |
| Gene name | cytosolic thiouridylase subunit 2 | protein kinase cAMP-dependent type II regulatory subunit alpha | |
| Synonyms | C16orf84|NCS2|UPF0432 | PKR2|PRKAR2 | |
| Cytomap | 16q24.3 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic tRNA 2-thiolation protein 2cytosolic thiouridylase subunit 2 homolog | cAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase regulatory subunit RII alphaprotein kinase A, RII-alpha subunitprotein kinase, cAMP-dependent, regulatory subunit type II alpha | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q2VPK5 | P13861 | |
| Ensembl transtripts involved in fusion gene | ENST00000453996, ENST00000378384, ENST00000312060, ENST00000567949, | ENST00000265563, ENST00000454963, ENST00000296446, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 7 X 5=210 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTU2 [Title/Abstract] AND PRKAR2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKAR2A | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 21812984 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK299521 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000453996 | ENST00000265563 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000453996 | ENST00000454963 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000453996 | ENST00000296446 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-3UTR | ENST00000378384 | ENST00000265563 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000378384 | ENST00000454963 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000378384 | ENST00000296446 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-3UTR | ENST00000312060 | ENST00000265563 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000312060 | ENST00000454963 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000312060 | ENST00000296446 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-3UTR | ENST00000567949 | ENST00000265563 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000567949 | ENST00000454963 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
| 5CDS-intron | ENST00000567949 | ENST00000296446 | CTU2 | chr16 | 88779212 | + | PRKAR2A | chr3 | 48786121 | - |
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FusionProtFeatures for CTU2_PRKAR2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTU2 | PRKAR2A |