|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8961 |
FusionGeneSummary for CTU2_MLYCD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTU2_MLYCD | Fusion gene ID: 8961 | Hgene | Tgene | Gene symbol | CTU2 | MLYCD | Gene ID | 348180 | 23417 |
| Gene name | cytosolic thiouridylase subunit 2 | malonyl-CoA decarboxylase | |
| Synonyms | C16orf84|NCS2|UPF0432 | MCD | |
| Cytomap | 16q24.3 | 16q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic tRNA 2-thiolation protein 2cytosolic thiouridylase subunit 2 homolog | malonyl-CoA decarboxylase, mitochondrialmalonyl coenzyme A decarboxylase | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q2VPK5 | O95822 | |
| Ensembl transtripts involved in fusion gene | ENST00000453996, ENST00000378384, ENST00000312060, ENST00000567949, | ENST00000262430, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CTU2 [Title/Abstract] AND MLYCD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MLYCD | GO:0006085 | acetyl-CoA biosynthetic process | 9869665|10417274|10455107 |
| Tgene | MLYCD | GO:0006633 | fatty acid biosynthetic process | 15003260 |
| Tgene | MLYCD | GO:2001294 | malonyl-CoA catabolic process | 10417274|10455107|15003260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1FD-01A | CTU2 | chr16 | 88779313 | + | MLYCD | chr16 | 83945823 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000453996 | ENST00000262430 | CTU2 | chr16 | 88779313 | + | MLYCD | chr16 | 83945823 | + |
| Frame-shift | ENST00000378384 | ENST00000262430 | CTU2 | chr16 | 88779313 | + | MLYCD | chr16 | 83945823 | + |
| Frame-shift | ENST00000312060 | ENST00000262430 | CTU2 | chr16 | 88779313 | + | MLYCD | chr16 | 83945823 | + |
| Frame-shift | ENST00000567949 | ENST00000262430 | CTU2 | chr16 | 88779313 | + | MLYCD | chr16 | 83945823 | + |
Top |
FusionProtFeatures for CTU2_MLYCD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTU2 | MLYCD |