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Fusion gene ID: 8912 |
FusionGeneSummary for CTSH_RASGRF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTSH_RASGRF1 | Fusion gene ID: 8912 | Hgene | Tgene | Gene symbol | CTSH | RASGRF1 | Gene ID | 1512 | 5923 |
| Gene name | cathepsin H | Ras protein specific guanine nucleotide releasing factor 1 | |
| Synonyms | ACC-4|ACC-5|ACC4|ACC5|CPSB | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | |
| Cytomap | 15q25.1 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pro-cathepsin HN-benzoylarginine-beta-naphthylamide hydrolasealeuraincathepsin B3cathepsin BA | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P09668 | Q13972 | |
| Ensembl transtripts involved in fusion gene | ENST00000220166, ENST00000534533, | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | |
| Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 3 X 4 X 3=36 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTSH [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTSH | GO:0002764 | immune response-regulating signaling pathway | 16822283 |
| Hgene | CTSH | GO:0006508 | proteolysis | 6203523|8811434 |
| Hgene | CTSH | GO:0010628 | positive regulation of gene expression | 21217776 |
| Hgene | CTSH | GO:0010813 | neuropeptide catabolic process | 15127951 |
| Hgene | CTSH | GO:0010815 | bradykinin catabolic process | 15127951 |
| Hgene | CTSH | GO:0010952 | positive regulation of peptidase activity | 20435891 |
| Hgene | CTSH | GO:0030335 | positive regulation of cell migration | 21217776 |
| Hgene | CTSH | GO:0031638 | zymogen activation | 20435891 |
| Hgene | CTSH | GO:0033619 | membrane protein proteolysis | 14766755 |
| Hgene | CTSH | GO:0043129 | surfactant homeostasis | 18216060 |
| Hgene | CTSH | GO:0070371 | ERK1 and ERK2 cascade | 21217776 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A27R-01A | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| TCGA | RV | LUAD | TCGA-86-8056-01A | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000220166 | ENST00000558480 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| Frame-shift | ENST00000220166 | ENST00000419573 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5CDS-intron | ENST00000220166 | ENST00000560334 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5CDS-intron | ENST00000220166 | ENST00000394745 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5UTR-3CDS | ENST00000534533 | ENST00000558480 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5UTR-3CDS | ENST00000534533 | ENST00000419573 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5UTR-intron | ENST00000534533 | ENST00000560334 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| 5UTR-intron | ENST00000534533 | ENST00000394745 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
| Frame-shift | ENST00000220166 | ENST00000558480 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| Frame-shift | ENST00000220166 | ENST00000419573 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| 5CDS-5UTR | ENST00000220166 | ENST00000560334 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| 5CDS-intron | ENST00000220166 | ENST00000394745 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| intron-3CDS | ENST00000534533 | ENST00000558480 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| intron-3CDS | ENST00000534533 | ENST00000419573 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| intron-5UTR | ENST00000534533 | ENST00000560334 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
| intron-intron | ENST00000534533 | ENST00000394745 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
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FusionProtFeatures for CTSH_RASGRF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTSH | RASGRF1 |