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Fusion gene ID: 8876 |
FusionGeneSummary for CTPS1_HIVEP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTPS1_HIVEP3 | Fusion gene ID: 8876 | Hgene | Tgene | Gene symbol | CTPS1 | HIVEP3 | Gene ID | 1503 | 59269 |
| Gene name | CTP synthase 1 | human immunodeficiency virus type I enhancer binding protein 3 | |
| Synonyms | CTPS|GATD5|IMD24 | KBP-1|KBP1|KRC|SHN3|Schnurri-3|ZAS3|ZNF40C | |
| Cytomap | 1p34.2 | 1p34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CTP synthase 1CTP synthetase 1UTP--ammonia ligase 1cytidine 5'-triphosphate synthetasecytidine 5-prime triphosphate synthetase | transcription factor HIVEP3ZAS family, member 3kappa-B and V(D)J recombination signal sequences-binding proteinkappa-binding protein 1zinc finger protein ZAS3 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P17812 | Q5T1R4 | |
| Ensembl transtripts involved in fusion gene | ENST00000372621, ENST00000541520, ENST00000475060, ENST00000543104, ENST00000372616, | ENST00000372583, ENST00000372584, ENST00000247584, ENST00000429157, ENST00000460604, | |
| Fusion gene scores | * DoF score | 6 X 7 X 6=252 | 12 X 9 X 8=864 |
| # samples | 7 | 13 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTPS1 [Title/Abstract] AND HIVEP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTPS1 | GO:0006241 | CTP biosynthetic process | 16179339 |
| Tgene | HIVEP3 | GO:0045893 | positive regulation of transcription, DNA-templated | 15790681 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-7078-01A | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000372621 | ENST00000372583 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-5UTR | ENST00000372621 | ENST00000372584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000372621 | ENST00000247584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000372621 | ENST00000429157 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000372621 | ENST00000460604 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000541520 | ENST00000372583 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-5UTR | ENST00000541520 | ENST00000372584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000541520 | ENST00000247584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000541520 | ENST00000429157 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| 5UTR-intron | ENST00000541520 | ENST00000460604 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000475060 | ENST00000372583 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-5UTR | ENST00000475060 | ENST00000372584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000475060 | ENST00000247584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000475060 | ENST00000429157 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000475060 | ENST00000460604 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000543104 | ENST00000372583 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-5UTR | ENST00000543104 | ENST00000372584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000543104 | ENST00000247584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000543104 | ENST00000429157 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000543104 | ENST00000460604 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000372616 | ENST00000372583 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-5UTR | ENST00000372616 | ENST00000372584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000372616 | ENST00000247584 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000372616 | ENST00000429157 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
| intron-intron | ENST00000372616 | ENST00000460604 | CTPS1 | chr1 | 41445501 | + | HIVEP3 | chr1 | 42384195 | - |
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FusionProtFeatures for CTPS1_HIVEP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTPS1 | HIVEP3 |