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Fusion gene ID: 8829 |
FusionGeneSummary for CTNNB1_BOLA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTNNB1_BOLA2 | Fusion gene ID: 8829 | Hgene | Tgene | Gene symbol | CTNNB1 | BOLA2 | Gene ID | 1499 | 654483 |
| Gene name | catenin beta 1 | bolA family member 2B | |
| Synonyms | CTNNB|EVR7|MRD19|armadillo | BOLA2 | |
| Cytomap | 3p22.1 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | catenin beta-1catenin (cadherin-associated protein), beta 1, 88kDa | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P35222 | Q9H3K6 | |
| Ensembl transtripts involved in fusion gene | ENST00000471014, ENST00000405570, ENST00000396183, ENST00000349496, ENST00000453024, ENST00000396185, | ENST00000330978, | |
| Fusion gene scores | * DoF score | 12 X 9 X 6=648 | 19 X 26 X 1=494 |
| # samples | 12 | 28 | |
| ** MAII score | log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTNNB1 [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTNNB1 | GO:0008285 | negative regulation of cell proliferation | 12970740 |
| Hgene | CTNNB1 | GO:0030997 | regulation of centriole-centriole cohesion | 18086858 |
| Hgene | CTNNB1 | GO:0032355 | response to estradiol | 15304487 |
| Hgene | CTNNB1 | GO:0033234 | negative regulation of protein sumoylation | 22155184 |
| Hgene | CTNNB1 | GO:0043065 | positive regulation of apoptotic process | 12651860|12970740 |
| Hgene | CTNNB1 | GO:0043525 | positive regulation of neuron apoptotic process | 19591802 |
| Hgene | CTNNB1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12970740|18787224 |
| Hgene | CTNNB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065402|11751639|12651860|14660579|18193033 |
| Hgene | CTNNB1 | GO:0060070 | canonical Wnt signaling pathway | 10644691|12937339|19187541 |
| Hgene | CTNNB1 | GO:0071681 | cellular response to indole-3-methanol | 10868478 |
| Hgene | CTNNB1 | GO:0090279 | regulation of calcium ion import | 19996314 |
| Hgene | CTNNB1 | GO:1904798 | positive regulation of core promoter binding | 22723415 |
| Hgene | CTNNB1 | GO:2000008 | regulation of protein localization to cell surface | 19996314 |
| Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK098472 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000471014 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| intron-3CDS | ENST00000405570 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| 3UTR-3CDS | ENST00000396183 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| 3UTR-3CDS | ENST00000349496 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| intron-3CDS | ENST00000453024 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
| 3UTR-3CDS | ENST00000396185 | ENST00000330978 | CTNNB1 | chr3 | 41281339 | + | BOLA2 | chr16 | 29465668 | - |
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FusionProtFeatures for CTNNB1_BOLA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTNNB1 | BOLA2 |