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Fusion gene ID: 8796 |
FusionGeneSummary for CTIF_GRM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTIF_GRM4 | Fusion gene ID: 8796 | Hgene | Tgene | Gene symbol | CTIF | GRM4 | Gene ID | 9811 | 2914 |
| Gene name | cap binding complex dependent translation initiation factor | glutamate metabotropic receptor 4 | |
| Synonyms | Gm672|KIAA0427 | GPRC1D|MGLUR4|mGlu4 | |
| Cytomap | 18q21.1 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CBP80/20-dependent translation initiation factor | metabotropic glutamate receptor 4glutamate receptor, metabotropic 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43310 | Q14833 | |
| Ensembl transtripts involved in fusion gene | ENST00000256413, ENST00000382998, ENST00000592658, | ENST00000538487, ENST00000374181, ENST00000374177, ENST00000544773, ENST00000545715, ENST00000535756, ENST00000609222, ENST00000455714, | |
| Fusion gene scores | * DoF score | 12 X 7 X 8=672 | 5 X 5 X 4=100 |
| # samples | 12 | 6 | |
| ** MAII score | log2(12/672*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTIF [Title/Abstract] AND GRM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRM4 | GO:0000187 | activation of MAPK activity | 15102938 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-B0-4945-01A | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000256413 | ENST00000538487 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000256413 | ENST00000374181 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000256413 | ENST00000374177 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000256413 | ENST00000544773 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000256413 | ENST00000545715 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000256413 | ENST00000535756 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000256413 | ENST00000609222 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000256413 | ENST00000455714 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000382998 | ENST00000538487 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000382998 | ENST00000374181 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000382998 | ENST00000374177 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| In-frame | ENST00000382998 | ENST00000544773 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000382998 | ENST00000545715 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000382998 | ENST00000535756 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000382998 | ENST00000609222 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| 5CDS-intron | ENST00000382998 | ENST00000455714 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-3CDS | ENST00000592658 | ENST00000538487 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-3CDS | ENST00000592658 | ENST00000374181 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-3CDS | ENST00000592658 | ENST00000374177 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-3CDS | ENST00000592658 | ENST00000544773 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-intron | ENST00000592658 | ENST00000545715 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-intron | ENST00000592658 | ENST00000535756 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-intron | ENST00000592658 | ENST00000609222 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
| intron-intron | ENST00000592658 | ENST00000455714 | CTIF | chr18 | 46197115 | + | GRM4 | chr6 | 34059876 | - |
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FusionProtFeatures for CTIF_GRM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTIF | GRM4 |