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Fusion gene ID: 8723 |
FusionGeneSummary for CTBP1_IGHJ6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTBP1_IGHJ6 | Fusion gene ID: 8723 | Hgene | Tgene | Gene symbol | CTBP1 | IGHJ6 | Gene ID | 1487 | 28475 |
| Gene name | C-terminal binding protein 1 | immunoglobulin heavy joining 6 | |
| Synonyms | BARS|HADDTS | JH6b | |
| Cytomap | 4p16.3 | 14q32.33 | |
| Type of gene | protein-coding | other | |
| Description | C-terminal-binding protein 1brefeldin A-ribosylated substrate | - | |
| Modification date | 20180522 | 20180329 | |
| UniProtAcc | Q13363 | ||
| Ensembl transtripts involved in fusion gene | ENST00000382952, ENST00000290921, ENST00000510568, ENST00000515690, | ENST00000390560, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 4 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTBP1 [Title/Abstract] AND IGHJ6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-66-2767-01A | CTBP1 | chr4 | 1229383 | - | IGHJ6 | chr14 | 106329456 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000382952 | ENST00000390560 | CTBP1 | chr4 | 1229383 | - | IGHJ6 | chr14 | 106329456 | - |
| intron-3CDS | ENST00000290921 | ENST00000390560 | CTBP1 | chr4 | 1229383 | - | IGHJ6 | chr14 | 106329456 | - |
| intron-3CDS | ENST00000510568 | ENST00000390560 | CTBP1 | chr4 | 1229383 | - | IGHJ6 | chr14 | 106329456 | - |
| intron-3CDS | ENST00000515690 | ENST00000390560 | CTBP1 | chr4 | 1229383 | - | IGHJ6 | chr14 | 106329456 | - |
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FusionProtFeatures for CTBP1_IGHJ6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTBP1 | IGHJ6 |