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Fusion gene ID: 868 |
FusionGeneSummary for ADD1_NEAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADD1_NEAT1 | Fusion gene ID: 868 | Hgene | Tgene | Gene symbol | ADD1 | NEAT1 | Gene ID | 118 | 283131 |
| Gene name | adducin 1 | nuclear paraspeckle assembly transcript 1 | |
| Synonyms | ADDA | LINC00084|NCRNA00084|TncRNA|VINC | |
| Cytomap | 4p16.3 | 11q13.1 | |
| Type of gene | protein-coding | ncRNA | |
| Description | alpha-adducinadducin 1 (alpha)erythrocyte adducin alpha subunit | MENepsilon/betalong intergenic non-protein coding RNA 84nuclear enriched abundant transcript 1nuclear paraspeckle assembly transcript 1 (non-protein coding)trophoblast MHC class II suppressortrophoblast-derived noncoding RNAvirus inducible non-codin | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P35611 | ||
| Ensembl transtripts involved in fusion gene | ENST00000446856, ENST00000264758, ENST00000398125, ENST00000513328, ENST00000503455, ENST00000355842, ENST00000398123, ENST00000398129, ENST00000538860, | ENST00000384994, | |
| Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 22 X 28 X 1=616 |
| # samples | 13 | 29 | |
| ** MAII score | log2(13/616*10)=-2.24441872766645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/616*10)=-1.08687745067997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADD1 [Title/Abstract] AND NEAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADD1 | GO:0032092 | positive regulation of protein binding | 3693401|7642559 |
| Hgene | ADD1 | GO:0051016 | barbed-end actin filament capping | 8626479 |
| Hgene | ADD1 | GO:0051017 | actin filament bundle assembly | 3693401 |
| Hgene | ADD1 | GO:0071277 | cellular response to calcium ion | 25978380 |
| Hgene | ADD1 | GO:1903142 | positive regulation of establishment of endothelial barrier | 25978380 |
| Hgene | ADD1 | GO:1903393 | positive regulation of adherens junction organization | 25978380 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI028313 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000446856 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000264758 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000398125 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000513328 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000503455 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000355842 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| intron-intron | ENST00000398123 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| 3UTR-intron | ENST00000398129 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
| intron-intron | ENST00000538860 | ENST00000384994 | ADD1 | chr4 | 2930765 | + | NEAT1 | chr11 | 65192235 | - |
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FusionProtFeatures for ADD1_NEAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADD1 | NEAT1 |