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Fusion gene ID: 8641 |
FusionGeneSummary for CSNK1E_DMC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSNK1E_DMC1 | Fusion gene ID: 8641 | Hgene | Tgene | Gene symbol | CSNK1E | DMC1 | Gene ID | 1454 | 283987 |
| Gene name | casein kinase 1 epsilon | HID1 domain containing | |
| Synonyms | CKIe|CKIepsilon|HCKIE | 17orf28|C17orf28|DMC1|HID-1 | |
| Cytomap | 22q13.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | casein kinase I isoform epsilon | protein HID1HID1 domain-containing proteinUPF0663 transmembrane protein C17orf28down-regulated in multiple cancers 1downregulated in multiple cancer 1protein hid-1 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49674 | Q14565 | |
| Ensembl transtripts involved in fusion gene | ENST00000359867, ENST00000396832, ENST00000400206, ENST00000403904, ENST00000413574, ENST00000405675, ENST00000498529, | ENST00000216024, ENST00000428462, ENST00000464842, | |
| Fusion gene scores | * DoF score | 11 X 8 X 10=880 | 3 X 3 X 3=27 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/880*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CSNK1E [Title/Abstract] AND DMC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
| Hgene | CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Hgene | CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
| Hgene | CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
| Hgene | CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
| Tgene | DMC1 | GO:0006886 | intracellular protein transport | 21337012 |
| Tgene | DMC1 | GO:0031001 | response to brefeldin A | 21337012 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AX-A2H4-01A | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000359867 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000359867 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000359867 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000396832 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000396832 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000396832 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| In-frame | ENST00000400206 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| In-frame | ENST00000400206 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000400206 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000403904 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000403904 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000403904 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000413574 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000413574 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000413574 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000405675 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000405675 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000405675 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-3CDS | ENST00000498529 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-3CDS | ENST00000498529 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-intron | ENST00000498529 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
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FusionProtFeatures for CSNK1E_DMC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSNK1E | DMC1 |