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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 8625

FusionGeneSummary for CSNK1A1_PDE6A

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1A1_PDE6A
Fusion gene ID: 8625
HgeneTgene
Gene symbol

CSNK1A1

PDE6A

Gene ID

1452

5145

Gene namecasein kinase 1 alpha 1phosphodiesterase 6A
SynonymsCK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975CGPR-A|PDEA|RP43
Cytomap

5q32

5q32

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77prod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaGMP-PDE alphaPDE V-B1cGMP phosphodiesterase alpha subunitphosphodiesterase 6A, cGMP-specific, rod, alpharod photoreceptor cGMP phosphodiesterase alpha subunit
Modification date2018052320180522
UniProtAcc

P48729

P16499

Ensembl transtripts involved in fusion geneENST00000261798, ENST00000377843, 
ENST00000515435, ENST00000504676, 
ENST00000515768, ENST00000606719, 
ENST00000606299, ENST00000515748, 
ENST00000255266, 
Fusion gene scores* DoF score7 X 6 X 6=2522 X 4 X 4=32
# samples 94
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSNK1A1 [Title/Abstract] AND PDE6A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

HgeneCSNK1A1

GO:0018105

peptidyl-serine phosphorylation

25500533


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A43M-01ACSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
TCGALDOVTCGA-13-1506-01ACSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
TCGALDUCECTCGA-EO-A1Y7-01ACSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261798ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
Frame-shiftENST00000377843ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
intron-3CDSENST00000515435ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
intron-3CDSENST00000504676ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
Frame-shiftENST00000515768ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
Frame-shiftENST00000606719ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
intron-3CDSENST00000606299ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
intron-3CDSENST00000515748ENST00000255266CSNK1A1chr5

148885010

-PDE6Achr5

149264430

-
In-frameENST00000261798ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
In-frameENST00000377843ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
In-frameENST00000515435ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
In-frameENST00000504676ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
In-frameENST00000515768ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
intron-3CDSENST00000606719ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
intron-3CDSENST00000606299ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
intron-3CDSENST00000515748ENST00000255266CSNK1A1chr5

148899853

-PDE6Achr5

149242829

-
Frame-shiftENST00000261798ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
Frame-shiftENST00000377843ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
5UTR-3CDSENST00000515435ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
5UTR-3CDSENST00000504676ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
Frame-shiftENST00000515768ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
intron-3CDSENST00000606719ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
intron-3CDSENST00000606299ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-
Frame-shiftENST00000515748ENST00000255266CSNK1A1chr5

148929638

-PDE6Achr5

149279087

-

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FusionProtFeatures for CSNK1A1_PDE6A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1A1

P48729

PDE6A

P16499