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Fusion gene ID: 8588

FusionGeneSummary for CSF3R_DAB2

Fusion gene summary

Fusion gene information	Fusion gene name: CSF3R_DAB2
	Fusion gene ID: 8588
		Hgene	Tgene
	Gene symbol	CSF3R	DAB2
	Gene ID	1441	1601
	Gene name	colony stimulating factor 3 receptor	DAB2, clathrin adaptor protein
	Synonyms	CD114\|GCSFR\|SCN7	DOC-2\|DOC2
	Cytomap	1p34.3	5p13.1
	Type of gene	protein-coding	protein-coding
	Description	granulocyte colony-stimulating factor receptorCD114 antigenG-CSF receptorG-CSF-Rcolony stimulating factor 3 receptor (granulocyte)	disabled homolog 2Dab, mitogen-responsive phosphoprotein, homolog 2adaptor molecule disabled-2differentially expressed in ovarian carcinoma 2differentially-expressed protein 2disabled homolog 2, mitogen-responsive phosphoprotein
	Modification date	20180523	20180519
	UniProtAcc	Q99062	P98082
	Ensembl transtripts involved in fusion gene	ENST00000373103, ENST00000373106, ENST00000373104, ENST00000361632, ENST00000331941, ENST00000487540, ENST00000418048, ENST00000338937, ENST00000440588,	ENST00000339788, ENST00000320816, ENST00000545653, ENST00000509337, ENST00000512525,
Fusion gene scores	* DoF score	1 X 1 X 1=1	6 X 7 X 2=84
	# samples	1	7
	** MAII score	log2(1/1*10)=3.32192809488736	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CSF3R [Title/Abstract] AND DAB2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DAB2	GO:0010718	positive regulation of epithelial to mesenchymal transition	15734730
Tgene	DAB2	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	11387212
Tgene	DAB2	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	11387212
Tgene	DAB2	GO:0043066	negative regulation of apoptotic process	15734730
Tgene	DAB2	GO:0060391	positive regulation of SMAD protein signal transduction	11387212

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BG006262	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000373103	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373103	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373103	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373103	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000373103	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373106	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373106	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373106	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373106	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000373106	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373104	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373104	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373104	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000373104	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000373104	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000361632	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000361632	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000361632	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000361632	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000361632	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000331941	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000331941	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000331941	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000331941	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000331941	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000487540	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000487540	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000487540	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000487540	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000487540	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000418048	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000418048	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000418048	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000418048	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000418048	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000338937	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000338937	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000338937	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000338937	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000338937	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000440588	ENST00000339788	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000440588	ENST00000320816	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000440588	ENST00000545653	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-3CDS	ENST00000440588	ENST00000509337	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+
intron-intron	ENST00000440588	ENST00000512525	CSF3R	chr1	36939400	+	DAB2	chr5	39393378	+

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FusionProtFeatures for CSF3R_DAB2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CSF3R Q99062	DAB2 P98082

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Fusion gene ID: 8588

FusionGeneSummary for CSF3R_DAB2

FusionProtFeatures for CSF3R_DAB2