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Fusion gene ID: 8585 |
FusionGeneSummary for CSF1R_RCOR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSF1R_RCOR1 | Fusion gene ID: 8585 | Hgene | Tgene | Gene symbol | CSF1R | RCOR1 | Gene ID | 1436 | 23186 |
| Gene name | colony stimulating factor 1 receptor | REST corepressor 1 | |
| Synonyms | C-FMS|CD115|CSF-1R|CSFR|FIM2|FMS|HDLS|M-CSF-R | COREST|RCOR | |
| Cytomap | 5q32 | 14q32.31-q32.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | macrophage colony-stimulating factor 1 receptorCD115 antigenCSF-1 receptorFMS proto-oncogeneMcDonough feline sarcoma viral (v-fms) oncogene homologmacrophage colony stimulating factor I receptorproto-oncogene c-Fms | REST corepressor 1 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P07333 | Q9UKL0 | |
| Ensembl transtripts involved in fusion gene | ENST00000286301, ENST00000515239, ENST00000543093, | ENST00000262241, ENST00000570597, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 7 X 4=168 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CSF1R [Title/Abstract] AND RCOR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSF1R | GO:0018108 | peptidyl-tyrosine phosphorylation | 20504948 |
| Hgene | CSF1R | GO:0046777 | protein autophosphorylation | 20504948 |
| Tgene | RCOR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10449787 |
| Tgene | RCOR1 | GO:0070933 | histone H4 deacetylation | 17555596 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI050908 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000286301 | ENST00000262241 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| intron-intron | ENST00000286301 | ENST00000570597 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| intron-intron | ENST00000515239 | ENST00000262241 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| intron-intron | ENST00000515239 | ENST00000570597 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| intron-intron | ENST00000543093 | ENST00000262241 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
| intron-intron | ENST00000543093 | ENST00000570597 | CSF1R | chr5 | 149449829 | + | RCOR1 | chr14 | 103084883 | + |
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FusionProtFeatures for CSF1R_RCOR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSF1R | RCOR1 |