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Fusion gene ID: 8562 |
FusionGeneSummary for CRYL1_SPACA7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRYL1_SPACA7 | Fusion gene ID: 8562 | Hgene | Tgene | Gene symbol | CRYL1 | SPACA7 | Gene ID | 51084 | 122258 |
| Gene name | crystallin lambda 1 | sperm acrosome associated 7 | |
| Synonyms | GDH|HEL30|gul3DH|lambda-CRY | C13orf28 | |
| Cytomap | 13q12.11 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44 | sperm acrosome-associated protein 7protein SPACA7 | |
| Modification date | 20180524 | 20180522 | |
| UniProtAcc | Q9Y2S2 | Q96KW9 | |
| Ensembl transtripts involved in fusion gene | ENST00000298248, ENST00000382812, ENST00000480748, | ENST00000283550, ENST00000375699, | |
| Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 3 X 3 X 3=27 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CRYL1 [Title/Abstract] AND SPACA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-B0-5117-01A | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000298248 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| Frame-shift | ENST00000298248 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| In-frame | ENST00000382812 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| In-frame | ENST00000382812 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| 5UTR-3CDS | ENST00000480748 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
| 5UTR-3CDS | ENST00000480748 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
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FusionProtFeatures for CRYL1_SPACA7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRYL1 | SPACA7 |