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Fusion gene ID: 8505 |
FusionGeneSummary for CRLF3_OPA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRLF3_OPA3 | Fusion gene ID: 8505 | Hgene | Tgene | Gene symbol | CRLF3 | OPA3 | Gene ID | 51379 | 80207 |
| Gene name | cytokine receptor like factor 3 | OPA3, outer mitochondrial membrane lipid metabolism regulator | |
| Synonyms | CREME-9|CREME9|CRLM9|CYTOR4|FRWS|p48.2 | MGA3 | |
| Cytomap | 17q11.2 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytokine receptor-like factor 3cytokine receptor-like molecule 9cytokine receptor-related protein 4type I cytokine receptor-like factor p48 | optic atrophy 3 proteinOptic atrophy 3 (Iraqi-Jewish 'optic atrophy plus')optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IUI8 | Q9H6K4 | |
| Ensembl transtripts involved in fusion gene | ENST00000324238, ENST00000544695, ENST00000577725, | ENST00000323060, ENST00000263275, ENST00000544371, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 8 X 7 X 4=224 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CRLF3 [Title/Abstract] AND OPA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CRLF3 | GO:0030308 | negative regulation of cell growth | 19427400 |
| Hgene | CRLF3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19427400 |
| Hgene | CRLF3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19427400 |
| Hgene | CRLF3 | GO:0046427 | positive regulation of JAK-STAT cascade | 19427400 |
| Hgene | CRLF3 | GO:0071158 | positive regulation of cell cycle arrest | 19427400 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-BF-A1Q0-01A | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000324238 | ENST00000323060 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| 5CDS-intron | ENST00000324238 | ENST00000263275 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| 5CDS-5UTR | ENST00000324238 | ENST00000544371 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| 5UTR-intron | ENST00000544695 | ENST00000323060 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| 5UTR-intron | ENST00000544695 | ENST00000263275 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| 5UTR-5UTR | ENST00000544695 | ENST00000544371 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| intron-intron | ENST00000577725 | ENST00000323060 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| intron-intron | ENST00000577725 | ENST00000263275 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
| intron-5UTR | ENST00000577725 | ENST00000544371 | CRLF3 | chr17 | 29151541 | - | OPA3 | chr19 | 46057169 | - |
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FusionProtFeatures for CRLF3_OPA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRLF3 | OPA3 |