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Fusion gene ID: 848 |
FusionGeneSummary for ADCY9_PRKCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY9_PRKCB | Fusion gene ID: 848 | Hgene | Tgene | Gene symbol | ADCY9 | PRKCB | Gene ID | 115 | 5579 |
| Gene name | adenylate cyclase 9 | protein kinase C beta | |
| Synonyms | AC9|ACIX | PKC-beta|PKCB|PRKCB1|PRKCB2 | |
| Cytomap | 16p13.3 | 16p12.2-p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase | protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O60503 | P05771 | |
| Ensembl transtripts involved in fusion gene | ENST00000294016, ENST00000571889, | ENST00000321728, ENST00000303531, ENST00000482000, ENST00000498058, | |
| Fusion gene scores | * DoF score | 18 X 5 X 10=900 | 13 X 9 X 10=1170 |
| # samples | 17 | 14 | |
| ** MAII score | log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1170*10)=-3.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADCY9 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADCY9 | GO:0006171 | cAMP biosynthetic process | 9628827|10987815 |
| Hgene | ADCY9 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | 9628827 |
| Tgene | PRKCB | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-33-4533-01A | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000294016 | ENST00000321728 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| In-frame | ENST00000294016 | ENST00000303531 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| 5CDS-intron | ENST00000294016 | ENST00000482000 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| 5CDS-intron | ENST00000294016 | ENST00000498058 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| intron-3CDS | ENST00000571889 | ENST00000321728 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| intron-3CDS | ENST00000571889 | ENST00000303531 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| intron-intron | ENST00000571889 | ENST00000482000 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
| intron-intron | ENST00000571889 | ENST00000498058 | ADCY9 | chr16 | 4163751 | - | PRKCB | chr16 | 23999829 | + |
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FusionProtFeatures for ADCY9_PRKCB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY9 | PRKCB |