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Fusion gene ID: 8463 |
FusionGeneSummary for CRIM1_EEF1B2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRIM1_EEF1B2 | Fusion gene ID: 8463 | Hgene | Tgene | Gene symbol | CRIM1 | EEF1B2 | Gene ID | 51232 | 1933 |
| Gene name | cysteine rich transmembrane BMP regulator 1 | eukaryotic translation elongation factor 1 beta 2 | |
| Synonyms | CRIM-1|S52 | EEF1B|EEF1B1|EF1B | |
| Cytomap | 2p22.2 | 2q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52 | elongation factor 1-betaEF-1-betaeukaryotic translation elongation factor 1 beta 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NZV1 | P24534 | |
| Ensembl transtripts involved in fusion gene | ENST00000280527, ENST00000473403, | ENST00000236957, ENST00000392221, ENST00000392222, | |
| Fusion gene scores | * DoF score | 10 X 8 X 6=480 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CRIM1 [Title/Abstract] AND EEF1B2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-BP-4774-01A | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000280527 | ENST00000236957 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| 5CDS-5UTR | ENST00000280527 | ENST00000392221 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| 5CDS-5UTR | ENST00000280527 | ENST00000392222 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| intron-intron | ENST00000473403 | ENST00000236957 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| intron-5UTR | ENST00000473403 | ENST00000392221 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
| intron-5UTR | ENST00000473403 | ENST00000392222 | CRIM1 | chr2 | 36669878 | + | EEF1B2 | chr2 | 207024637 | + |
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FusionProtFeatures for CRIM1_EEF1B2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRIM1 | EEF1B2 |