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Fusion gene ID: 8433 |
FusionGeneSummary for CREBBP_KAT6B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREBBP_KAT6B | Fusion gene ID: 8433 | Hgene | Tgene | Gene symbol | CREBBP | KAT6B | Gene ID | 1387 | 23522 |
| Gene name | CREB binding protein | lysine acetyltransferase 6B | |
| Synonyms | CBP|KAT3A|RSTS|RSTS1 | GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf | |
| Cytomap | 16p13.3 | 10q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CREB-binding protein | histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q92793 | Q8WYB5 | |
| Ensembl transtripts involved in fusion gene | ENST00000262367, ENST00000382070, | ENST00000372725, ENST00000372724, ENST00000287239, ENST00000372714, ENST00000372711, ENST00000490365, | |
| Fusion gene scores | * DoF score | 25 X 18 X 14=6300 | 4 X 5 X 2=40 |
| # samples | 34 | 5 | |
| ** MAII score | log2(34/6300*10)=-4.21174517713694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CREBBP [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
| Hgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
| Hgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24939902 |
| Hgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
| Hgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Hgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
| Hgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
| Tgene | KAT6B | GO:0016573 | histone acetylation | 11965546 |
| Tgene | KAT6B | GO:0043966 | histone H3 acetylation | 16387653 |
| Tgene | KAT6B | GO:0045892 | negative regulation of transcription, DNA-templated | 10497217 |
| Tgene | KAT6B | GO:0045893 | positive regulation of transcription, DNA-templated | 10497217|11965546 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AJ299262 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000262367 | ENST00000372725 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000262367 | ENST00000372724 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000262367 | ENST00000287239 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| In-frame | ENST00000262367 | ENST00000372714 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000262367 | ENST00000372711 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| 5CDS-intron | ENST00000262367 | ENST00000490365 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000382070 | ENST00000372725 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000382070 | ENST00000372724 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000382070 | ENST00000287239 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| In-frame | ENST00000382070 | ENST00000372714 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| Frame-shift | ENST00000382070 | ENST00000372711 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
| 5CDS-intron | ENST00000382070 | ENST00000490365 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
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FusionProtFeatures for CREBBP_KAT6B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREBBP | KAT6B |