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Fusion gene ID: 8420 |
FusionGeneSummary for CREB5_NUDCD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREB5_NUDCD2 | Fusion gene ID: 8420 | Hgene | Tgene | Gene symbol | CREB5 | NUDCD2 | Gene ID | 9586 | 134492 |
| Gene name | cAMP responsive element binding protein 5 | NudC domain containing 2 | |
| Synonyms | CRE-BPA|CREB-5 | NudCL2 | |
| Cytomap | 7p15.1 | 5q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 5cAMP response element-binding protein CRE-BPa | nudC domain-containing protein 2NudC-like protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q02930 | Q8WVJ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000396299, ENST00000357727, ENST00000396300, ENST00000409603, ENST00000396298, ENST00000482692, | ENST00000302764, ENST00000517501, ENST00000519395, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CREB5 [Title/Abstract] AND NUDCD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREB5 | GO:0045893 | positive regulation of transcription, DNA-templated | 8378084 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA737108 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000396299 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396299 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396299 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-3UTR | ENST00000357727 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000357727 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000357727 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-3UTR | ENST00000396300 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396300 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396300 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-3UTR | ENST00000409603 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000409603 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000409603 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-3UTR | ENST00000396298 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396298 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000396298 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-3UTR | ENST00000482692 | ENST00000302764 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000482692 | ENST00000517501 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
| intron-intron | ENST00000482692 | ENST00000519395 | CREB5 | chr7 | 28585247 | - | NUDCD2 | chr5 | 162880624 | + |
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FusionProtFeatures for CREB5_NUDCD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREB5 | NUDCD2 |