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Fusion gene ID: 8305 |
FusionGeneSummary for CPSF1_ARHGAP39 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPSF1_ARHGAP39 | Fusion gene ID: 8305 | Hgene | Tgene | Gene symbol | CPSF1 | ARHGAP39 | Gene ID | 29894 | 80728 |
| Gene name | cleavage and polyadenylation specific factor 1 | Rho GTPase activating protein 39 | |
| Synonyms | CPSF160|HSU37012|P/cl.18 | CrGAP|Vilse | |
| Cytomap | 8q24.3 | 8q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cleavage and polyadenylation specificity factor subunit 1CPSF 160 kDa subunitcleavage and polyadenylation specific factor 1, 160kDacleavage and polyadenylation specificity factor 160 kDa subunitpolyadenylation specificity factor | rho GTPase-activating protein 39RhoGAP93B homologcrossGAP homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q10570 | Q9C0H5 | |
| Ensembl transtripts involved in fusion gene | ENST00000349769, ENST00000531727, | ENST00000540274, ENST00000377307, ENST00000276826, ENST00000528810, | |
| Fusion gene scores | * DoF score | 7 X 7 X 7=343 | 7 X 6 X 6=252 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/343*10)=-2.10013667128545 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CPSF1 [Title/Abstract] AND ARHGAP39 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A9RU-01A | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| TCGA | RV | STAD | TCGA-BR-8678-01A | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000349769 | ENST00000540274 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| 5CDS-intron | ENST00000349769 | ENST00000377307 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| 5CDS-intron | ENST00000349769 | ENST00000276826 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| 5CDS-5UTR | ENST00000349769 | ENST00000528810 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| intron-intron | ENST00000531727 | ENST00000540274 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| intron-intron | ENST00000531727 | ENST00000377307 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| intron-intron | ENST00000531727 | ENST00000276826 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| intron-5UTR | ENST00000531727 | ENST00000528810 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145763197 | - |
| Frame-shift | ENST00000349769 | ENST00000540274 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| Frame-shift | ENST00000349769 | ENST00000377307 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| Frame-shift | ENST00000349769 | ENST00000276826 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| 5CDS-intron | ENST00000349769 | ENST00000528810 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| intron-3CDS | ENST00000531727 | ENST00000540274 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| intron-3CDS | ENST00000531727 | ENST00000377307 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| intron-3CDS | ENST00000531727 | ENST00000276826 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
| intron-intron | ENST00000531727 | ENST00000528810 | CPSF1 | chr8 | 145634399 | - | ARHGAP39 | chr8 | 145806661 | - |
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FusionProtFeatures for CPSF1_ARHGAP39 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPSF1 | ARHGAP39 |