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Fusion gene ID: 827 |
FusionGeneSummary for ADCY2_SH3BGRL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY2_SH3BGRL3 | Fusion gene ID: 827 | Hgene | Tgene | Gene symbol | ADCY2 | SH3BGRL3 | Gene ID | 108 | 83442 |
| Gene name | adenylate cyclase 2 | SH3 domain binding glutamate rich protein like 3 | |
| Synonyms | AC2|HBAC2 | HEL-S-297|SH3BP-1|TIP-B1 | |
| Cytomap | 5p15.31 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | SH3 domain-binding glutamic acid-rich-like protein 3SH3 domain binding glutamic acid-rich protein like 3SH3 domain-binding protein 1SH3BGRL3-like proteinTNF inhibitory proteinepididymis secretory protein Li 297 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q08462 | Q9H299 | |
| Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000270792, ENST00000319041, | |
| Fusion gene scores | * DoF score | 20 X 19 X 5=1900 | 4 X 4 X 2=32 |
| # samples | 21 | 4 | |
| ** MAII score | log2(21/1900*10)=-3.17753818555219 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ADCY2 [Title/Abstract] AND SH3BGRL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ896787 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000338316 | ENST00000270792 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| intron-intron | ENST00000338316 | ENST00000319041 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| intron-5UTR | ENST00000537121 | ENST00000270792 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| intron-intron | ENST00000537121 | ENST00000319041 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| intron-5UTR | ENST00000513693 | ENST00000270792 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
| intron-intron | ENST00000513693 | ENST00000319041 | ADCY2 | chr1 | 152009422 | + | SH3BGRL3 | chr1 | 26606586 | + |
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FusionProtFeatures for ADCY2_SH3BGRL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY2 | SH3BGRL3 |