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Fusion gene ID: 8260 |
FusionGeneSummary for CPNE1_ASIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPNE1_ASIP | Fusion gene ID: 8260 | Hgene | Tgene | Gene symbol | CPNE1 | ASIP | Gene ID | 8904 | 56288 |
| Gene name | copine 1 | par-3 family cell polarity regulator | |
| Synonyms | COPN1|CPN1 | ASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2 | |
| Cytomap | 20q11.22 | 10p11.22-p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | copine-1chromobindin 17copine I | partitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q99829 | P42127 | |
| Ensembl transtripts involved in fusion gene | ENST00000352393, ENST00000317677, ENST00000397445, ENST00000317619, ENST00000397443, ENST00000397446, ENST00000397442, ENST00000475146, | ENST00000568305, ENST00000374954, | |
| Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 6 X 2 X 4=48 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CPNE1 [Title/Abstract] AND ASIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CPNE1 | GO:0043392 | negative regulation of DNA binding | 18212740 |
| Hgene | CPNE1 | GO:0045666 | positive regulation of neuron differentiation | 23263657 |
| Hgene | CPNE1 | GO:0051897 | positive regulation of protein kinase B signaling | 23263657 |
| Hgene | CPNE1 | GO:1990138 | neuron projection extension | 23263657 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-G2-AA3B-01A | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000352393 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000352393 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000317677 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000317677 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397445 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397445 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000317619 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000317619 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397443 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397443 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397446 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397446 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397442 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000397442 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000475146 | ENST00000568305 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
| intron-5UTR | ENST00000475146 | ENST00000374954 | CPNE1 | chr20 | 34214143 | - | ASIP | chr20 | 32848173 | + |
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FusionProtFeatures for CPNE1_ASIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPNE1 | ASIP |